| 单扫示波极谱法测定氧氟沙星 |
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| 引用本文： | 钱永贵,尚军,李启隆,鲁毅强. 单扫示波极谱法测定氧氟沙星[J]. 分析试验室, 2001, 20(2): 83-86 |
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| 作者姓名： | 钱永贵 尚军 李启隆 鲁毅强 |
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| 作者单位： | 1. 北京师范大学化学系,
2. 北京科技大学化学系, |
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| 基金项目： | 国家自然科学基金!资助项目 ( No.2 98750 0 3 ) |
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| 摘 要： | 在 0 .1 5mol/L HAc- Na Ac( p H 3.64)中 ,采用单扫示波极谱法测定氧氟沙星 ,得到一良好的还原峰 ,峰电位 Ep=- 1 .45V( vs.SCE)。峰电流 IP与氧氟沙星的浓度在 3.0× 1 0 - 7～ 6.2× 1 0 - 6 mol/L范围内呈线性关系 ,相关系数 r=0 .9983,检出限为 7.0× 1 0 - 8mol/L。此法已用于片剂的测定。用线性扫描和循环伏安法研究了体系性质 ,结果表明 ,氧氟沙星的电极过程为具有吸附性的不可逆过程。
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| 关 键 词： | 氧氟沙星 单扫示波极谱法 伏安行为 抗菌药 药物分析 |
| 文章编号： | 1000-0720(2001)02-0083-04 |
Determination of Ofloxacin by Single-sweep Oscillopolarography |
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| QIAN Yong gui,SHANG Jun,LI Qi long. Determination of Ofloxacin by Single-sweep Oscillopolarography[J]. Chinese Journal of Analysis Laboratory, 2001, 20(2): 83-86 |
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| Authors: | QIAN Yong gui SHANG Jun LI Qi long |
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| Abstract: | The ofloxacin showed a sensitive derivative reduction peak at-1.45V(vs.SCE) by using single-sweep oscilloploarography in a buffer solution of 0.15 mol/L HAc-NaAc (pH 3.64). The peak current was proportional to the concentration of ofloxacin in the range of 3.0×10-7～6.2×10-6 mol/L with r=0.9983. The detection limit is 7.0×10-8 mol/L .This method was applied to determine the ofloxacin in tablets with satisfactory results.The electrochemical behavior and reaction mechanism of the system were studied at a hanging mercury drop electrode by linear and cyclic voltammetry. The electrode reduction process of ofloxacion at Hg electrodes was irreversible with adsorptive characteristics. |
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| Keywords: | Ofloxacin Single sweep oscillopolarography Voltammetric behavior |
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