氟哌啶醇季铵盐衍生物对冠状动脉作用的研究

观察氟哌啶醇季铵盐衍生物对冠状动脉的作用。方法：利用氟哌啶醇所致小鼠锥体外不良反应模型。观察其衍生物（Ｆ３）的作用；利用猪冠状动脉条生物鉴定。观察Ｆ（１０＾－６，１０＾－５ａｎｄ１０＾－４ｍｏＬ／Ｌ＿对ＫＣｌ（１０－４０ｍｍｏＬ／Ｌ）诱导的冠脉条收缩的拮抗作用，阻断由ＫＣｌ（４０ｍｍｏ／Ｌ）诱导的冠脉条的收缩；利用豚鼠离体心脏灌注，观察Ｆ３（１０＾－６，５＊１０＾－６，１０＾－５ｍｏＬ／Ｌ）拮抗脑

Effect of Quaternary Ammonium Salt Derivation of Haloperidol on Coronary Artery

Objective: To observe the effect of quaternary ammonium salt derivation of haloperidol on coronary artery. Method: By using the model of adverse reaction of extrapyramidal system induced by haloperidol ip on mice, to observe the behavior effect of its derivation(F3)on same dose and administration. Using the bioassay of porcine coronary artery strips, F3(10-6, 10-5 and 10-4moL/L)were added into the bath medium prior to KCl(10～40mmoL/L)administration to observe the effect of F3 on dose-response curve of contraction induced by KCl, and the block action of F3(10-4moL/L)on the contraction induced by KCl respectively; Using the Langendorff perfusion, to observe the effect of F3(10-6 , 5×10-6, 10-5moL/L)on reduction of coronary artery flow of guinea-pig induced by pituitrin. Results: Haloperidol induced Parkinsons like syndrome, but F3 could not induce the same effect. F3 decreased coronary artery strips contraction curve induced by KCl in dose-dependent manner. F3 also blocked the contraction induced by KCl. F3 antagonized the reduction of coronary flow induced by pituitrin on isolated heart of guinea-pig in dose-dependent manner. Conclusion: F3 caused coronary artery dilation as haloperidol , and did not cause any adverse reaction of extrapyramidal system as it.