血清IMA联合血浆D-二聚体对比螺旋CT对肺栓塞患者的诊断指导意义

目的 探讨联合检测缺血修饰蛋白(IMA)及D-二聚体在肺栓塞(PE)患者的诊断价值、病情判断方面的指导意义.方法 收集了近7年来该院确诊的及疑似的肺栓塞患者56例,将确诊PE患者30例、非PE患者(疑似患者)26例、健康志愿者30例进行研究,并将PE患者30例分成3亚组:高危组、中危组、低危组,记录其外周血IMA、D-二聚体数值.并将结果与CT肺动脉造影(CTPA)结果进行对照.结果 PE组患者IMA、D-二聚体数值显著升高,相比非PE组、健康受试组具有统计学差异.与CTPA结果相符.PE患者亚组分析:高危组、中危组中IMA、D-二聚体水平相比低危组明显升高,但高危、中危组间比较没有统计学差异.结论 肺栓塞患者中,缺血修饰蛋白、D-二聚体水平越高,患者的危险分层越高,病情越重.对于可疑的肺栓塞患者,检测IMA、D-二聚体可以帮助急性肺栓塞的的诊断.

The diagnostic value of detected IMA combined D-dimer and controled with spiral CT in pulmonary embolism patients

Objective Discussion on the guiding significance of diganosis and judging the condition of pulmonary embolism (PE) by detected ischemia modified albumin (IMA) and D-dimer.Methods Collected 56 cases diagnosed and suspected PE patients in our hospital nearly 7 years. Then,they were divided into 3 groups, confirmed group 30 cases, suspected group 26 cases and the healthy control group 30 cases. Meanwhile,the PE group was divided into 3 parts:high-risk group, moderate-risk group and low-risk group. Recorded the results of IMA and D-dimer. The result will be compared with CT pulmonary angiography.Results The values of IMA and D-dimer in PE group were significantly higher than non-PE group and healthy control group, it had a significant difference. This result was consistent with the CTPA results. PE patients subgroups showed:the values of IMA and D-dimer in high-risk group and moderate-risk group were significantly higher than low-risk group, but there was no sigificant different between high-risk group and moderate-risk group. Conclusion The PE patients with higher risk stratification had a higher levels of IMA and D-dimer, the more severe condition of them. For patients with suspected PE, detection IMA and D-dimer were helpful in the diagnosis of acut PE.