| 左旋千金藤定碱抗心律失常作用的研究 |
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| 引用本文： | 苏彦宏,李慧兰.左旋千金藤定碱抗心律失常作用的研究[J].昆明医学院学报,2009,30(10):23-25. |
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| 作者姓名： | 苏彦宏 李慧兰 |
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| 作者单位： | 1. 昆明医学院第一附属医院心内科,云南,昆明,650032
2. 昆明医学院药理教研室,云南,昆明,650031 |
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| 摘 要： | 目的研究左旋千金藤定碱（L-stepholidine,SPD）抗心律失常的作用.方法采用实验性动物心律失常模型,探讨SPD的抗心律失常效应.结果SPD对BaCl2诱发的大鼠心律失常有明显的对抗作用,并能显著降低CaCl2所致大鼠的室颤发生率和死亡率,对强心苷所致的心律失常也有明显的保护作用.结论SPD具有明显的抗心律失常作用.
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| 关 键 词： | 左旋千金藤定碱 心律失常 保护作用 |
Anti-Arrhythmic Effects of L-stepholidine |
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| Affiliation: | SU Yan - hong , LI Hui - lan (1) Dept. of Cardiology, The 1st Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650032; 2) Dept. of Pharmacology, Kunming Medical University, Kunming Yunnan 650031, China) |
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| Abstract: | Objective To observe anti-arrthythmic effects of L-stepholidine anti-arrhythmic effects of SPD were investigated on experimental arrhythmic animal （SPD）. Methods The models trigged by BaCl2, CaCl2, or cardiac glycosides （digoxin, strophanthin K, and lanatoside）. Results SPD was able to antagonize arrhythmia trigged by BaCl2 in rats, and was able to decrease ventricular fibrillation incidence and mortality trigged by CaCl2 in rats, further more, SPD showed protective effects on arrhythmia caused by cardiac glycosides in guinea pigs. Conclusion SPD has significant anti-arrhythmic effects. |
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| Keywords: | L-stepholidine Arrhythmina Protective effects |
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