高血糖素及其受体研究进展

在治疗2型糖尿病的药物中，西药见效快但有副作用，如磺脲类药物会引起体重增加；中药注重整体调节，但起效慢。因此，研制快速起效且安全可靠的药物是治疗2型糖尿病的关键。高血糖素是胰岛α细胞分泌的多肽激素，主要作用于肝脏，可促进肝糖原分解，抑制肝糖原合成，促进葡萄糖异生、分解，其受体拮抗剂可能是治疗2型糖尿病的有效药物。该文就高血糖素及其受体的研究进展作一论述。

Progress of Studies on Glucagon and Glucagon Receptor

Among the medicine treating type 2 diabetes, the Western medicine is effective, but has adverse reactions, such as biguanides could cause body weight gain; the traditional Chinese medicine is concept of wholism,but is less sensitive. So it is significant to develop effective and safe drug treating type 2 diabetes. Glucagon is a kind of peptide hormones sercreted by pancreatic island α- cell, which accelerates glycogenolysis and gluconeogenesis and restrains glycogenesis. The receptor blocker of glucagon is conceivably effective on treating type 2 diabetes mellitus. The progress of research on glucagon and glucagon receptor is discussed.