| 雷公藤中的一种新活性成分一16-羟基雷公藤内酯醇 |
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| 引用本文： | 马鹏程,吕燮余,杨晶晶,郑启泰. 雷公藤中的一种新活性成分一16-羟基雷公藤内酯醇[J]. 中国药学, 1992, 0(2) |
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| 作者姓名： | 马鹏程 吕燮余 杨晶晶 郑启泰 |
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| 作者单位： | 中国医学科学院皮肤病研究所 南京210042(马鹏程，吕燮余)，中国医学科学院药物研究所 北京100050(杨晶晶，郑启泰) |
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| 摘 要： | 从雷公藤(Tripterygiurn wilfordii Hook f.)的叶、根及制剂“雷公藤多甙”中分离出一个新的三环氧二萜内酯化合物-16-羟基雷公藤内酯醇(L_2)。该化合物是一种白色簇状结晶,熔点232-233.5℃,分子式为C_20H_24O_7。根据光谱(UV,IR,MS,~1HNMR,~13CNMR,2d-NMR和Se-lective Long-range DEPT)数据分析,确定了其化学结构,并通过X-射线晶体分析确证了它的立体化学。15-C为“S”构型的手性碳。药理试验表明,16-羟基雷公藤内酯醇具有较强的抗炎、免疫抑制和雄性抗生育活性。另外,还分离到已知化合物雷公藤内酯醇,并通过2d-NMR等光谱分析归属了全部碳和质子的NMR光谱峰。
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| 关 键 词： | 雷公藤 二萜内酯 环氧二萜 16-羟基雷公藤内酯醇 雷公藤内酯醇 |
16-Hydroxytriptolide" An Active Compound from Tripterygium wilfordii |
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| Peng-Cheng Ma, Xie-Yu Lu, Jing-Jing Yang, Qi-Tai Zheng. 16-Hydroxytriptolide" An Active Compound from Tripterygium wilfordii[J]. Journal of Chinese Pharmaceutical Sciences, 1992, 0(2) |
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| Authors: | Peng-Cheng Ma Xie-Yu Lu Jing-Jing Yang Qi-Tai Zheng |
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| Affiliation: | Peng-Cheng Ma1, Xie-Yu Lu1, Jing-Jing Yang2, Qi-Tai Zheng21. Institute of Dermatology,Chinese Academy of Medical Sciences,Nanjing 210042:2. Institute of Materia Medica. Chinese Academy of Medical Sciences,Beijing 100050 |
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| Abstract: | From the dried roots and leaves of Tripterygium wilfordii~(1.2),a new diter- penoid triepoxide,16-hydroxytriptolide was isolated,and its structure and stereochemistry elucidated as 16-(S)-hydroxy-triptolide on the basis of spectral data(IR, MS, UV,~1HNMR,~(13)CNMR,2d-NMR,Selective Long-range DEPT)and x-ray crystallographic analysis.This compound showed definite antiinflammatory action,strong immunosuppressive and antifertile activities.In addition,a known compound,triptolide was also isolated and all the spectral signals of~1 HNMR and ~(13)CNMR were assigned. |
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| Keywords: | Tripterygium wilfordii Diterpenoid lactone Diterpenoid epoxide 16-Hy-droxytriptolide Triptolide |
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