氯氮平剂量与心电图异常的关系探讨

目的 观察抗精神病药物氯氮平的剂量对心电图异常的影响.方法 对持续服用氯氮平治疗2年以上的81例精神分裂症患者服用不同剂量的氯氮平时的心电图检查结果进行回顾性分析.结果 氯氮平≥200 mg/d有35例患者,其中27例有心电图异常,占77.14％；＜200 mg/d有46例患者,其中24例有心电图异常,占52.17％,两组差异有统计学意义(x2=5.13,P＜0.05)；两组心电图异常均以T波异常占首位,窦性心动过速居第二位.结论 患者心电图的异常改变和氯氮平的剂量存在着一定的关系,并随着用药剂量的增加而增多.

Investigation on the relationship between clozapine dose and electrocardiogram abnormalities

Objective To observe the antipsychotic clozapine dose to the influence of the abnormal ecg. Methods The continuous use elozapine 2 years of treatment for 81 cases of schizophrenia patients taken different doses of ecg examination results were retrospectively analyzed. Results≥200mg/d quartile group 35 examples have 27 cases who had electrocardiogram abnormalities, the abnormal rate was 77.14% , 〈 200mg group 46 patients had 24 cases who had electrocardiogram abnormalities, the abnormal rate was 52.17% , there were significant differences, the two groups was statistically significant（ χ2 = 5.13, P 〈 0.05 ） , two of which were all with abnormal wave of first, T sinus tachycardia in the second. Conclusion The change with the patient＇s electrocardiogram dosage had certain relations. Patients with abnormal ecg situation of may increase with drug doses increasing.