蛇床子素对肾性高血压大鼠心肌肥厚的治疗作用

目的观察蛇床子素对肾性高血压诱导大鼠心肌肥厚的治疗作用并探讨其可能的机制。方法采用两肾一夹建立肾性高血压大鼠心肌肥厚模型，用蛇床子素（10mg／kg和20mg／kg）治疗4周后检测大鼠血压、心质量指数及心肌超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）含量、血糖及血和心肌游离脂肪酸（FFA）含量。用光镜检查心肌组织的病理学变化。结果蛇床子素可降低心肌肥厚大鼠的血压、心质量指数、心肌MDA含量和血及心肌FFA含量，尤其是大剂量组的作用更为明显（P〈0．05或P〈0．01），同时蛇床子素也能明显升高心肌SOD和GSH-P含量及血糖水平（P〈0．05或P〈0．01）。光镜检查结果显示蛇床子素组大鼠心肌肥厚程度减轻。结论蛇床子素能治疗肾陛高血压诱导的大鼠心肌肥厚，其主要机制可能与抑制氧化应激和改善心肌能量代谢有关。

Therapeutic effect of osthole on renovascular hypertension-induced cardiac hypertrophy in rats

Objective To investigate the therapeutic effect of osthole on renovascular hypertension- induced cardiac hypertrophy in rats and its possible mechanisms. Methods A rat model with cardiac hy- pertrophy was established by two kidney-one clip, and these rats were then treated with osthole 10 mg/kg and 20 mg/kg for 4 weeks. At the end of the experiment, the blood pressure, heart mass index, myocar- dial superoxide dismutase （ SOD）, glutathione peroxidase （GSH-Px） and malondialdehyde （MDA） con- tents, blood glucose and free fatty acids （FFA） in serum and myocardium were measured. Pathomorpho- logical changes of myocardial tissue were examined by light microscope. Results After treatment with os- thole, the blood pressure, heart mass index, MDA in myocaiMium, and FFA in serum and myocardium were lowered, especially in the osthole 20 mg/kg group （ P 〈 0.05 or P 〈 0.01 ）, while the blood glu- cose, the myocardial SOD and GSH-Px contents were obviously increased （P 〈 0.05 or P 〈 0.01 ）. More- over, the histological evaluation demonstrated that osthole could alleviate the degree of myocardial hyper- trophy in rats. Conclusion Osthole was effective in the treatment of renovascular hypertension-induced cardiac hypertrophy in rats, and the main mechanisms might be related to its inhibition of oxidative stress and improvement of myocardial energy metabolism.