影响肝细胞癌术后长期生存的相关因素

通过对复旦大学肝癌研究所20世纪90年代手术治疗的2333例肝细胞癌病例的分析,旨在寻找与长期生存的相关因素.其中根治性切除1465(62.8%)例,姑息性切除868例(37.2%).随访至2003年底,术后存活5年以上者527例,其中根治性切除组454例,姑息性切除组73例.根治性切除后长期生存的相关因素为肿瘤的发现途径,肿瘤大小、包膜,肿瘤细胞的分化程度,肝硬化程度,血清γ-GT水平.姑息性切除后长期生存的相关因素为肿瘤大小、肿瘤包膜、γ-GT、肝硬化程度、术后TACE和二步切除是长期生存独立的影响因素.术后复发的病人经过综合治疗后也能达到比较理想的长期生存率.

Relevant factors to long-term survival after surgical treatment of hepatocellular carcinoma

In order to investigate the relevant factors to long-term survival after surgical treatment of hepatocellular carcinoma(HCC),clinicopathic data of 2333 patients treated at Liver Cancer Institute of Fudan University in 1990s were analysed.HCC with radical resetion(1465)or with palliative surgical treatment(868)were analysed seperately.By the end of 2003,527 patients had survived over 5 years,454 in radical resection group,and 73 in the other group.Factors that HCC detected by screening,tumour size,tumour capsula,tumour differentiation,cirrhosis,and serum r-GT were significantly related to long-term survival in radical resection group.Factors that tumour size,tumour capsula,cirrhosis,post-operative transcathetter arterial chemoembolization,down staging resection were significantly related to long-term survival in palliative surgical treatment group.Besides,comprehensive treatment for recurrence HCC can achieve a well long-term survival rate.