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胎儿颈部软组织厚度产前超声筛查的价值
引用本文:陈彦红,许春梅,严思萍,马刚,莫伟英,黄向红,康利克,张永兵,沈桂新,杨金兰,农美芬,陈美芳.胎儿颈部软组织厚度产前超声筛查的价值[J].广西医科大学学报,2003,20(5):649-651.
作者姓名:陈彦红  许春梅  严思萍  马刚  莫伟英  黄向红  康利克  张永兵  沈桂新  杨金兰  农美芬  陈美芳
作者单位:广西壮族自治区人民医院 南宁 530021
基金项目:广西科技厅科学研究与技术开发计划资金资助项目 (桂科攻 98170 95 )
摘    要:目的:探讨超声测量胎儿颈部软组织厚度(Nuchal Skinfold Thickness,NT)在检出染色体异常疾病21-三体综合征中的价值。方法:经腹超声测量3203例中晚孕期胎儿颈部软组织厚度,并进行统计分析及与染色体核型分析作对照。结果:在3203例胎儿中,NT增厚者有162例,其中4例为21-三体,假阳性为158例,假阴性2例,其敏感性为66.67%,特异性为95.06%,准确性为95%。结论:超声测量胎儿NT值,对21-三体胎儿的筛查有重要的参考价值。不失为一种简便、安全、可重复、非侵入性、孕妇易于接受的新方法。

关 键 词:胎儿  颈部软组织厚度  产前筛查  超声测量  21-三体综合征
修稿时间:2003年5月28日

VALUE OF THE NUCHAL SKINFOLD THICKNESS OF FETUS IN PRENATAL SCRE-ENING WITH ULTRASONOGRAPHY
Chen Yanhong,Xu Chunmei,Yan Siping,et al..VALUE OF THE NUCHAL SKINFOLD THICKNESS OF FETUS IN PRENATAL SCRE-ENING WITH ULTRASONOGRAPHY[J].Journal of Guangxi Medical University,2003,20(5):649-651.
Authors:Chen Yanhong  Xu Chunmei  Yan Siping  
Abstract:Objective:To study the value of the Nuchal Skinfold Thickness (NT) of fetus in diagnosis of fetal 21-trisomy syndrome.Methods:NT of 3 203 fetuses from middle to late gestation were measured with ultrasonography and the results were statistically analyzed. NT was compared with the karyotype analysis.Result:162 fetuses had the thicker NT among the 3 203 fetuses,and 4 of them were 21-trisomy syndrome. The false positivity and false negative were 158 and 2 respectively.The sensitivity,specficity and accuracy of ultrasonography were 66.67%,95.06% and 95%.Conclusion:The ultrasonographic measurement data of NT have an important reference value in prenatal screening of fetal 21-trisomy syndrome.It is a new method of convenience, safety, repeat ability and nonintrusion. It is welcome by pregnant women.
Keywords:ultrasonography  21-trisomy syndrome  nuchal skinfold thickness  prenatal  screening
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