高剂量瑞舒伐他汀对急性脑梗死患者血脂及血清hs-CRP的影响

目的 研究高剂量瑞舒伐他汀对急性脑梗死患者患者血脂及血清超敏C-反应蛋白(hs-CRP)的影响.方法 90例急性脑梗死患者随机数字表均分为对照组和观察组,每组45例.对照组患者以瑞舒伐他汀10 mg/d治疗,观察组患者以瑞舒伐他汀20 mg/d治疗,观察2组患者临床症状,测定2组患者治疗前后颈动脉内膜中层厚度(IMT),血脂总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C),血清hs-CRP水平变化情况.同时测定白介素-6 (IL-6)、肿瘤坏死因子-α(TNF-α)水平.结果 2组患者经治疗后的斑块面积和颈动脉IMT均较治疗前显著降低,差异有统计学意义(P＜0.05),且观察组治疗后斑块面积和颈动脉IMT低于对照组,差异有统计学意义(P＜0.05);2组患者血脂TC、TG、LDL-C水平均较治疗前明显下降,而HDL-C水平则相对升高,差异均有统计学意义(P＜0.05),观察组血脂水平改善情况明显好于对照组(P＜0.05).经治疗2组患者hs-CRP、IL-6和TNF-α水平均显著降低;且观察组hs-CRP、IL-6和TNF-α水平均明显低于对照组,差异均有统计学意义(P＜0.05).结论 高剂量瑞舒伐他汀可更好地稳定颈动脉粥样硬化斑块,并降低急性脑梗死患者患者血脂及血清hs-CRP的水平,能够更有效的抵抗炎性反应.

Effects of high-dose atorvastatin on serum lipids and serum levels of hs-CRP in patients with acute cerebral infarction

Objective To investigate the effects of high-dose atorvastatin on blood lipids and serum levels of hs-CRP in patients with acute cerebral infarction.Methods Ninety patients with acute cerebral infarction who were admitted and treated in our hospital from March 2015 to March 2016 were divided into control group (n =45) and observation group (n =45) according to random number table.The patients in control group were treated by rosuvastatin (10mg/d),however,the patients in observation group were treated by rosuvastatin (20mg/d).The clinical symptoms were observed for both groups.The carotid artery IMT,blood lipids levels including TC,TG,HDL-C and LDL-C,the changes of serum levels of hs-CRP,IL-6 and TNF-α before and after treatment were observed and compared between two groups.Results After treatment,the area of plaque and carotid artery IMT were significantly decreased,as compared with those before treatment in both groups (P ＜ 0.05),moreover,which in observation group were significantly lower than those in control group (P ＜0.05).After treatment the serum levels of TC,TG,LDL-C were significantly decreased,but HDL-C levels were increased relatively,as compared with those before treatment in both groups (P ＜ 0.05),moreover,the improvement status of blood lipids levels in observation group was superior to that in control group (P ＜ 0.05).After treatment,the serum levels of hs-CRP,IL-6 and TNF-α were significantlydecreased in both groups,moreover,the serum levels of hs-CRP,IL-6 and TNF-α in observation group were significantly lower than those in control group (P ＜ 0.05).Conclusion The high-dose rosuvastatin can more effectively stabilize carotid atherosclerotic plaques,and can reduce the serum levels of blood lipids and hs-CRP in patients with acute cerebral infarction,and can resist inflammatory reaction more effectively.