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| 银黄制剂的HPLC-ELSD指纹图谱研究 | |
| 引用本文： | 赵刚,杜玮,魏玉辉,姚小军,武新安. 银黄制剂的HPLC-ELSD指纹图谱研究[J]. 中草药, 2009, 40(7): 1053-1056 |
| 作者姓名： | 赵刚 杜玮 魏玉辉 姚小军 武新安 |
| 作者单位： | 1. 兰州大学第一医院药剂科,甘肃,兰州,730000;兰州大学药学院,甘肃,兰州,730000 2. 兰州大学第一医院药剂科,甘肃,兰州,730000 3. 兰州大学药学院,甘肃,兰州,730000 |
| 摘 要： | 目的 建立稳定可控的银黄制剂的HPLC-ELSD的指纹图谱.探讨主成分分析法和聚类分析法在中药制剂指纹图谱中的应用.方法 用梯度洗脱法对样品进行HPLC-ELSD测定,且采用聚类分析和主成分分析法对不同厂家和批次的样品图谱进行化学模式识别研究.结果 建立的银黄制剂指纹图谱表征了不同厂家和批次的制剂之间的客观差异.结论 聚类分析和主成分分析法能有效地应用于是银黄制剂的指纹图谱分析,为有效的控制该制剂的质量提供评价依据. |
| 关 键 词： | 银黄制剂 指纹图谱 聚类分析法 主成分分析法 质量控制 |
| 收稿时间： | 2008-11-16 |
HPLC-ELSD Fingerprints of Yinhuang preparations |
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| ZHAO Gang,DU Wei,WEI Yu-hui,YAO Xiao-jun and WU Xin-an. HPLC-ELSD Fingerprints of Yinhuang preparations[J]. Chinese Traditional and Herbal Drugs, 2009, 40(7): 1053-1056 | |
| Authors: | ZHAO Gang DU Wei WEI Yu-hui YAO Xiao-jun WU Xin-an |
| Affiliation: | Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000,China;College of Pharmacy,Lanzhou University,Lanzhou 730000,China;Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000,China;College of Pharmacy,Lanzhou University,Lanzhou 730000,China;Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000,China;College of Chemistry and Chemical Enginnering,Lanzhou University,Lanzhou 730000,China;Department of Pharmacy,the First Hospital of Lanzhou University,Lanzhou 730000,China |
| Abstract: | Objective To evaluate the quality of Yinhuang preparations effectively and develop a credi-ble method for the quality control of Chinese materia medica. Methods Fingerprints of different Yinhuang preparations were obtained by HPLC-ELSD method. The technique of projection discriminate study based on hierarchical cluster analysis and principal component analysis ,was applied to investigate the experimen-tal data. Results The developed fingerprints showed that there were differences among the Yin-huang preparation by different manufacturers. Conclusion This method using the hierarchical cluster analysis and principal component analysis could be effectively applied to the quality control of Chinese rnateria medica. |
| Keywords: | Yinhuang preparations fingerprints hierarchical cluster analysis principal component analysis quality control |
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