邯郸市妇女空气污染暴露对妊娠期高血压的影响

选择河北省邯郸市某医院孕妇数据,探讨了6项空气污染物暴露对孕妇患妊娠期高血压(GH)的影响和不同人群的效应差异,采用传统Logistic回归模型评估了各项污染物的效应,采用主成分改进的Logistic回归模型评估了各项污染物在额外调整其它污染物后的效应.结果显示,单污染物模型中,妊娠期前26周每20μg/m3增量的O3...

Maternal exposure to ambient air pollution and gestational hypertension in Handan

The traditional logistic regression model was used to evaluate the effects of exposure to various pollutants on GH, and the logistic regression model based on principal component analysis was used to evaluate the effects on GH by additionally adjusting parameters of other pollutants. Results of single-pollutant model showed that each 20μg/m³ increment of O₃ was significantly positively correlated with the increased risk of GH (OR=1.211, 95%CI: 1.094~1.340) during the first 26 weeks of gestation, and the effect in the first trimester was greater than that in the second trimester. In multi-pollutant model, each 20μg/m³ increment of PM_2.5 and PM₁₀ exposure significantly increased the GH risk of pregnant women in the three months before pregnancy, with OR values of 1.021 (95%CI: 1.004~1.038) for PM_2.5 and 1.016 (95%CI: 1.002~1.031) for PM₁₀. Consistent with the results of single-pollutant model, each 20μg/m³ increment of O₃ exposure also had a significant effect on the risk of GH (OR=1.026, 95%CI: 1.002~1.050) during the first 26 weeks of gestation in multi-pollutant model. The results of subgroup analysis showed that pregnant women aged 25~30 years or those in the first pregnancy were susceptible to PM_2.5, PM₁₀, NO₂ and CO exposure before pregnancy, while pregnant women over 35 years old or without college degrees were more likely to develop GH due to O₃ exposure during pregnancy. In summary, air pollution in Handan has significant impacts on pregnant women inducing suffering from GH. To mitigate the negative impacts of exposure to air pollution, more attention should be paid to the enhancement of air pollution protection awareness for pregnant women before and during pregnancy.