| 氧化铁磁性纳米粒子的制备、表面修饰及在分离和分析中的应用 |
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| 引用本文： | 赵紫来,卞征云,陈朗星,何锡文,王彦芬. 氧化铁磁性纳米粒子的制备、表面修饰及在分离和分析中的应用[J]. 化学进展, 2006, 18(10): 1288-1297 |
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| 作者姓名： | 赵紫来 卞征云 陈朗星 何锡文 王彦芬 |
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| 作者单位： | 南开大学化学系,天津,300071;南开大学化学系,天津,300071;南开大学化学系,天津,300071;南开大学化学系,天津,300071;南开大学化学系,天津,300071 |
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| 摘 要： | 氧化铁磁性纳米粒子通过表面化学修饰得到无机、有机或聚合物壳包覆在其表面。其中的壳结构既具有生物适应性,又具有可键合生物分子如细胞、蛋白质、酶、抗体和核酸的活性基团,而核具有磁性特性。本文总结了氧化铁磁性纳米粒子的制备方法,介绍了其表面化学修饰及在分离和分析应用的最新进展。
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| 关 键 词： | 氧化铁 磁性纳米粒子 制备 表面修饰 磁性分离 生化检测 |
| 文章编号： | 1005-281X（2006）10-1288-10 |
| 收稿时间： | 2005-11-01 |
| 修稿时间： | 2006-02-01 |
Synthesis and Surface-Modifications of Iron Oxide Magnetic Nanoparticles and Applications on Separation and Analysis |
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| Zhao Zilai,Bian Zhengyun,Chen Langxing,He Xiwen,Wang Yanfen. Synthesis and Surface-Modifications of Iron Oxide Magnetic Nanoparticles and Applications on Separation and Analysis[J]. Progress in Chemistry, 2006, 18(10): 1288-1297 |
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| Authors: | Zhao Zilai Bian Zhengyun Chen Langxing He Xiwen Wang Yanfen |
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| Affiliation: | Department of Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | Iron oxide magnetic nanoparticles with biocompatibility and functional coatings via appropriate surface chemistry approaches have been used for immobilization of cells,proteins,enzymes,antibodies,oligonucleotides and drugs through covalent bonding or adsorption.The surface-modified magnetic nanoparticles have been widely used in biological and biomedical areas such as immobilization of biomolecules;separation of metal ions,cells,proteins,DNA;immunoassay,biochemical analysis and magnetic resonance imaging(MRI) probes.In this paper,preparation methods,surface modification approaches and analytical applications of iron oxide-based magnetic nanoparticles are reviewed. |
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| Keywords: | iron oxide magnetic nanoparticles synthesis surface modification magnetic separation biochemical analysis |
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