Fibronectin peptide DRVPHSRNSIT and fibronectin receptor peptide DLYYLMDL arrest gastrulation ofRana pipiens |
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Authors: | X. Wang C. A. Lessman D. B. Taylor T. K. Gartner |
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Affiliation: | (1) Department of Biology, University of Memphis, 38152 Memphis, Tennessee, USA;(2) Department of Biology, Illinois Benedictine College, 60532 Lisle, Illinois, USA |
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Abstract: | Gastrulation is characterized by dramatic cell migration which is thought to require the interaction of cell adhesion molecules with extracellular molecules. We have tested two novel peptides, a fibronectin peptide and a fibronectin receptor peptide, for their effects on gastrulation of the leopard frogRana pipiens. The fibronectin peptide DRVPHSRNSIT corresponds to residues 1373–1383 of the cell-binding domain of fibronectin; the receptor peptide DLYYLMDL corresponds to residues 124–131 of 1 subunit of a variety of integrins including 51. Either of these peptides significantly inhibited gastrulation after being microinjected into mid-blastulae. These results indicate that these sequences may correspond to the ligand/receptor interaction sites of fibronectin and its receptor(s). |
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Keywords: | Fibronectin fibronectin receptor peptides gastrulation Rana pipiens embryo |
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