| Design and Synthesis of Chiral Molecular Tweezers Based on Deoxycholic Acid |
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| 作者姓名： | Cui Hua XUE Qi Ming MU Shu Hua CHEN* The Faculty of chemistry Sichuan University Chengdu |
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| 作者单位： | Cui Hua XUE，Qi Ming MU，Shu Hua CHEN* The Faculty of chemistry，Sichuan University，Chengdu 610064 |
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| 摘 要： | Molecular tweezers is a novel type of artificial receptors, which not only offer the advantage of efficient construction but also their surfaces can be tailored for specific applications. The clefts of molecular tweezers are particularly effective in regard to complementarity with substrates since functional groups attached to the interior of the cleft converge on substrates held inside1. So, in recent years, the molecular tweezers receptors have attracted more and more attention in molecular …
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Design and Synthesis of Chiral Molecular Tweezers Based on Deoxycholic Acid |
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| Cui Hua XUE,Qi Ming MU,Shu Hua CHEN* The Faculty of chemistry,Sichuan University,Chengdu .Design and Synthesis of Chiral Molecular Tweezers Based on Deoxycholic Acid[J].Chinese Chemical Letters,2001(5). |
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| Authors: | Cui Hua XUE Qi Ming MU Shu Hua CHEN The Faculty of chemistry Sichuan University Chengdu |
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| Affiliation: | Cui Hua XUE,Qi Ming MU,Shu Hua CHEN* The Faculty of chemistry,Sichuan University,Chengdu 610064 |
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| Abstract: | A series of new chiral molecular tweezers have been designed and synthesized by using deoxycholic acid as spacer and aromatic amines as arms. Instead of using toxic phosgene, the triphosgene was employed in synthesis of the molecular tweezers receptors. These chiral molecular tweezers showed good enantioselectivity for D-amino acid methyl esters. |
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| Keywords: | Molecular tweezers synthesis deoxycholic acid recognition |
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