| 雷公藤多苷片对佐剂性关节炎大鼠血清SOD含量影响的实验研究 |
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| 引用本文： | 王永萍,马萍,蔡小青,张曼,刘志娟,王风洲.雷公藤多苷片对佐剂性关节炎大鼠血清SOD含量影响的实验研究[J].山西中医学院学报,2009,10(5):16-18. |
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| 作者姓名： | 王永萍 马萍 蔡小青 张曼 刘志娟 王风洲 |
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| 作者单位： | 1. 贵阳中医学院,贵州,贵阳,550002
2. 成都中医药大学,四川,成都,610025 |
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| 摘 要： | 目的：研究雷公藤多苷片对佐剂性关节炎大鼠血清中超氧化物歧化酶（SOD）含量的影响。方法：将40只Wistar大鼠随机分成正常对照组、模型组、雷公藤多苷片治疗组（雷公藤组）、泼尼松治疗组（泼尼松组）4组，每组10只。造模后第8天、第12天、第16天、第20天、第24天测量大鼠左后踝关节周径，计算关节炎指数；第28天取血，检测血清中超氧化物歧化酶（SOD）含量。结果：与模型组比较，雷公藤组大鼠左足跖肿胀度及关节炎指数显著降低（P〈0．05，P〈0．01），血清中SOD含量显著升高。结论：雷公藤多苷片除具有较强的抗炎及免疫抑制作用外，还具有抗氧化作用。
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| 关 键 词： | 雷公藤多苷片 佐剂性关节炎 抗氧化作用 |
Effects of Azathioprine Tablet on Serum SOD Contents of Adjuvant Arthritis Model Rats |
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| Wang Yongping,Ma Ping,Cai Xiaoqing,Zhang Man,Liu Zhijuan,Wang Fengzhou.Effects of Azathioprine Tablet on Serum SOD Contents of Adjuvant Arthritis Model Rats[J].Journal of Shanxi College of Traditional Chinese Medicine,2009,10(5):16-18. |
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| Authors: | Wang Yongping Ma Ping Cai Xiaoqing Zhang Man Liu Zhijuan Wang Fengzhou |
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| Affiliation: | 1.Guizhou College of TCM, Guiyang Guizhou 550002 ;2. Chengdu Univercity of TCM, Chengdu Sichuan 610025) |
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| Abstract: | Objective ：To observe effects of azathioprine tablet on serum SOD contents of adjuvant arthritis model rats. Method：40 Wistar rats were randomly divided into normal control group, model group,azathioprine tablet treatment group （azathioprine group）and prednisone acetate tablet group（prednisone acetate group）. After the model rats were constructed,ankle joint diameter of rats was measured and arthritis index （AI）of rats was calculated on days 8,12, 14, 16,20,24; serum SOD contents of rats were detected on day 28. Result： Compared with model group,diameter of ankle joint and AI of rats were significantly decreased,serum SOD contents of rats were significantly increased in azathioprine group. Conclusion：Apart from anti-inflammatory action and immunosuppressive action,azathioprine posesses antioxidation. |
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| Keywords: | azathioprine tablet adjuvant arthritis antioxidation |
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