| 绿茶及其有效成分对肾性高血压大鼠左心室肥厚的抑制作用 |
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| 引用本文： | 毛伟峰,宋雁,王伟,韩驰,李宁.绿茶及其有效成分对肾性高血压大鼠左心室肥厚的抑制作用[J].中国食品卫生杂志,2009,21(2). |
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| 作者姓名： | 毛伟峰 宋雁 王伟 韩驰 李宁 |
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| 作者单位： | 中国疾病预防控制中心营养与食品安全所,北京,100050 |
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| 基金项目： | “十一五”国家科技支撑计划(2006NAK02A07) |
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| 摘 要： | 目的研究绿茶及其有效成分对肾性高血压大鼠左心室肥厚的抑制作用。方法雄性Wistar大鼠160只,体重180～220g,随机分为5组,建立二肾一夹法大鼠肾性高血压左心室肥厚模型。假手术组(Sham),正常饮水;阳性对照组(二肾一夹法,2K1C),正常饮水;绿茶组(二肾一夹法加绿茶水,2K1C+GT),饮用2%绿茶水;茶多酚组(二肾一夹法加茶多酚水,2K1C+TP),饮用0.1%茶多酚水;表没食子儿茶素没食子酸酯(EGCG)组(二肾一夹法加EGCG水,2K1C+EGCG),饮用0.05% EGCG水,术后即给予不同浓度的绿茶及其提有效成分,持续8周。分别于实验第0、4、8周测量血压。8周后处死测量左心室与体重比值(LVW/BW)和左心室壁厚度(LVWT),检测胚胎基因-心房利钠肽(embryonic gene atria natriuretic peptide,ANP),并对部分心肌组织HE染色进行病理组织学观察。结果与假手术组比较,阳性对照组和各饮茶组血压、LVW/BW和LVWT均显著升高(P<0.01)。而与阳性对照组相比,不同浓度的绿茶及其有效成分(2%绿茶、0.1%茶多酚、0.05% EGCG)LVW/B...
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| 关 键 词： | 茶 儿茶素 高血压 肾性 肥大 左心室 生物医学研究 |
Effects of Green Tea and Tea Extracts on Left Ventricle Hypertrophy Induced by Renovascular Hypertension in Rats |
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| MAO Wei-feng,SONG Yan,WANG Wei,HAN Chi,LI Ning.Effects of Green Tea and Tea Extracts on Left Ventricle Hypertrophy Induced by Renovascular Hypertension in Rats[J].Chinese Journal of Food Hygiene,2009,21(2). |
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| Authors: | MAO Wei-feng SONG Yan WANG Wei HAN Chi LI Ning |
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| Affiliation: | National Institute for Nutrition and Food Safety;Chinese CDC;Beijing 100050;China |
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| Abstract: | Objective To investigate the preventive effects and the molecular mechanisms of green tea and tea extracts (polyphenols and EGCG) on left ventricle hypertrophy (LVH) induced by renovascular hypertension in rats.Method One hundred and sixty male Wistar rats were randomly divided into five groups: negative control group (Sham), positive control group (2K1C), green tea group (2KIC+GT), tea polyphenol group (2K1C+TP), EGCG group (2K1C+EGCG). After surgery operation, rats in different groups received tap water, ... |
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| Keywords: | Tea Catechin Hypertension Renal Hypertrophy Left Ventricular Biomedical Research |
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