| 神经母细胞瘤骨髓转移23例临床病理分析 |
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| 引用本文： | 王凤华,张美德,夏健清,曾荣新.神经母细胞瘤骨髓转移23例临床病理分析[J].临床与实验病理学杂志,2008,24(4). |
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| 作者姓名： | 王凤华 张美德 夏健清 曾荣新 |
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| 作者单位： | 广州市儿童医院病理科,广州,510120 |
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| 摘 要： | 目的 探讨神经母细胞瘤骨髓转移的临床病理特征.方法 对23例神经母细胞瘤骨髓转移的临床病理资料进行分析,并做光镜观察及免疫组化染色.结果 神经母细胞瘤骨髓转移表现为微小浸润、中度浸润和弥漫浸润三种形式,主要根据骨髓造m组织与肿瘤成分的比例和分布而定,其中微小浸润常需行CgA/NSE免疫组化染色辅助诊断.结论 神经母细胞瘤骨髓转移的诊断需结合临床、光镜及免疫组化,以提高检出率并鉴别于横纹肌肉瘤、骨Ewing肉瘤、淋巴母细胞淋巴瘤/白血病.
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| 关 键 词： | 神经母细胞瘤 骨髓 转移 |
Clinicopathological features of bone marrow metastasis of neuroblastoma |
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| WANG Feng-hua,ZHANG Mei-de,XIA Jian-qing,ZENG Rong-xin.Clinicopathological features of bone marrow metastasis of neuroblastoma[J].Chinese Journal of Clinical and Experimental Pathology,2008,24(4). |
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| Authors: | WANG Feng-hua ZHANG Mei-de XIA Jian-qing ZENG Rong-xin |
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| Affiliation: | Department of Pathology;Guangzhou Children's Hospital;Guangzhou 510120;China |
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| Abstract: | Purpose To study the clinicopathological features of bone marrow (BM) metastasis of neuroblastoma (NB). Methods Twenty-three cases of neuroblastoma with bone marrow metastasis were reviewed and studied by light microscopy and immunohistochemical staining. Results There were three morphological types of BM metastasis of NB, microinvasive, moderately invasive and diffusely invasive pattern. CgA/NSE immunohistochemical staining was needed for confirming the metastatic neuroblastic cells in microinvasion. Concl... |
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| Keywords: | neuroblastoma bone marrow metastasis |
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