Influence of accompanying anion on intestinal radiocalcium absorption |
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Authors: | Xavier Marchandise Dominique Pagniez Hubert Ythier Bernard Gilquin Bernard Duquesnoy Jean-Louis Wemeau |
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Affiliation: | (1) Centre Hospitalier de Lille, 2 Avenue O. Lambret, 59037 Lille Cedex, France;(2) Laboratoire de Biophysique, Faculté de Médecine, 59045 Lille Cedex, France |
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Abstract: | Summary To assess directly the effect of ionic dissociation on the bioavailability of calcium, we used the double isotope inverse
convolution method to compare the absorption of calcium gluconate and calcium pyrrolidone carboxylate, an organic, highly
dissociated salt. Two tests were performed at a 2 day interval, using in random sequence either salt as a carrier. Forty-eight
subjects of various age and clinical condition were studied. The use of the more dissociated salt consistently and significantly
increased fractional absorption in a rather constant ratio. Moreover, it slowed absorption in normal subjects whatever their
age, and accelerated it in patients with chronic renal failure or osteoporosis, leading to inferences on the alteration of
calcium absorption in these conditions. |
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Keywords: | Calcium absorption Calcium salts Osteoporosis |
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