维持性血液透析病人NK－IL－2－IFNr系统的动态观察

本文检测了４０例维持性血液透析（ＭＨＤ）患者自然杀伤细胞（Ｎｋ）活性，并同时检测了患者外周血单个核细胞（ＰＢＭＣ）在植物血凝素（ＰＨＡ）刺激下白细胞介素２（ＩＬ－２）和免疫干扰素（ＩＦＮｒ）产生水平。结果发现ＭＨＤ患者ＮＫ活性、ＩＬ－２活性和ＩＦｖｒ水平均显著低于正常对照组（Ｐ＜０．０１）；单次血液透析后ＭＨＤ患者的ＮＫ活性、ＩＬ－２和ＩＦＮｒ诱生水平均有不同程度的升高；长期血液透析对ＮＫ活性、ＩＬ－２和ＩＦＶｒ诱生水平影响不大，正常对照ＮＫ活性与ＰＢＭＣ诱生ＩＬ－２和ＩＦＮｒ水平存在直线正相关，而ＭＨＤ患者相关性无显著意义，但透析后ＭＨＤ患者ＮＫ活性与ＩＬ－２活性相关性有显著意义。提示：ＭＮＤ淋巴细胞存在多方面功能受损，包括免疫调节环路的紊乱；血液透析能部分纠正这些免疫学异常；但长期血液透析无助于改善ＭＨＤ病人的免疫功能受损。

AMBULATORY STUDY OF NK CELL ACTIVI-TY AND IL- 2 AND IFN r PRODUCTlON IN VITROIN PAllENTS ON MAINTENANCE HEMODIALYSIS

e assayed NK cell cytotoxicity against K562 tar-gets in 40 patients on MHD, and the production level ofIL-2 and IFN r in peripheral blood normal controls.The results showed that NK cell activity. level of IL-2 and IFN r were markedly lower than those of thecontrols. After single dialysis, the activity and the levelwere markedly elevated, but there were no significantlychange compared with long term dialysis. There was apositive correlation between the NK ceil activity andthe level of iL-2 and IFN r in the controls, but to cor-relation in.he patients. These abnormal iinmune sta-tus in patients could be partly corrected by hemodialy-sis, but long term hemodialysis was unable to recoverthem.