| Abstract: | Objective:To study the therapeutic effects of epidermal growth factor (EGF) and platelet-derived wound healing factor (PDWHF) on the nonhealing cutaneous ulcers in 78 patients with diabetes mellitus. Methods: Seventy-eight patients were divided into group A in which the patients were treated with saline to serve as the control, group B in which the patients were treated with EGF and group C treated with PDWHF. General healing practice was administered. Wound closure index, healing rate and histological changes of the ulcerative wounds of the patients were observed in the treatment period of 8 weeks. Results:The wond closure index and healing rate were more significantly increased in groups B and C than in group A of the control with far more angiogenesis , fibroblast hyperplasia and collagen deposition in the former than in the latter. The therapeutic effects of PDWHF seemed to be superior to those of EGF.Conclusion :It is suggested that the local application of a certain growth factor or of a combination of several growth factors in an efficient management to improve the healing of diabetic cutaneous ulcers. |
