| 角质细胞生长因子及其受体在口腔扁平苔藓和口腔鳞状细胞癌中表达的研究 |
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| 引用本文： | 李洪平,黎春晖,聂敏海,康晓洁,缪克红.角质细胞生长因子及其受体在口腔扁平苔藓和口腔鳞状细胞癌中表达的研究[J].泸州医学院学报,2011,34(5):623-626. |
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| 作者姓名： | 李洪平 黎春晖 聂敏海 康晓洁 缪克红 |
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| 作者单位： | 泸州医学院附属口腔医院口腔内科,四川泸州,646000 |
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| 基金项目： | 泸州市重点科技计划项目(2009-S-17) |
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| 摘 要： | 目的：探讨角质细胞生长因子（KGF）及其受体（KGFR）在口腔扁平苔藓（OLP）和口腔鳞状细胞癌（OSCC）的表达及意义。方法：运用免疫组化SP法研究KGF及KGFR在糜烂型、非糜烂型OLP,高、中、低分化OSCC中的表达。结果：KGF在糜烂型和非糜烂型OLP中的表达差异无统计学意义,在高、中、低分化OSCC中表达差异也无统计学意义,但KGFR在非糜烂型OLP、正常口腔黏膜（NOM）、糜烂型OLP表达逐渐增强,差异具有统计学意义,KGFR在高、中、低分化OSCC中表达逐渐减弱,差异有统计学意义。结论：KGF对OLP,OSCC发生可能并不起关键作用。KGFR可能是影响口腔黏膜上皮细胞增殖的重要因素,可能与OLP的发病有关,且可作为监测OLP癌变的早期指标,KGFR还可能与OSCC的分化程度有关。
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| 关 键 词： | KGF KGFR 口腔扁平苔藓 口腔鳞状细胞癌 |
EXPRESSION OF KGF AND KGFR IN ORAL LICHEN PLANUS AND ORAL SQUAMOUS CELL CARCINOMA |
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| Li Hongping,et al.EXPRESSION OF KGF AND KGFR IN ORAL LICHEN PLANUS AND ORAL SQUAMOUS CELL CARCINOMA[J].Journal of Luzhou Medical College,2011,34(5):623-626. |
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| Authors: | Li Hongping |
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| Affiliation: | Li Hongping,et al Department of Oral Medicine,the Affiliated Stomatology Hospital of Luzhou Medical College |
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| Abstract: | Objective: To explore the expression of keratinocyte growth factor(KGF) and its receptor(KGFR) in oral lichen planus(OLP) and oral squamous cell carcinoma(OSCC) and its significance.Methods: Immunohist-ochemical SP method was applied to detect the expression of KGF and KGFR in erosive,non-erosive OLP and well,moderately,poorly differentiated OSCC.Results: There was no significant difference in the expression of KGF in erosive and non-erosive OLP,no significant difference in well,moderately and poorly differ... |
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| Keywords: | Keratinocyte growth factor Keratinocyte growth factor receptor Oral lichen planus Oral squamous cell carcinoma |
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