中药药代动力学研究进展

中药制剂组分较为复杂，作用靶点较多，其药代动力学研究与仅关注单一成分或生物效应的经典药代动力学研究具有较大的差异。近年来，为了全面阐述中药吸收、分布、代谢、排泄的体内过程，推动中药现代化，中药药代动力学成为近年来兴起的中药研究新领域，研究者们在血药浓度法、生物效应法和药动／药效学模型结合法等经典药代动力学研究方法的基础上提出了中药整合药代动力学、药代标志物、指征药代动力学和中药复方谱动学新研究方法等中药药代动力学研究新方法、新思路，大大推进了中药药代动力学研究的发展。查阅通过近年来中药药代动力学相关研究的文献，并对其中新方法新思路进行总结，综述了中药药代动力学近年来的研究现况和前沿进展。

Research Progress in Pharmacokinetics Research of Traditional Chinese Medicine

Traditional Chinese medicine （TCM） is a kind of pharmaceutics with complicate content and muhiple targets. The pharmacokinetics research of TCM is significantly different from the research of classic western medicine which only focuses on single compound or effect. Recently, in order to fully understand the ADME process of TCM and make a contribution to the modernization of TCM industry, pharmacokinetics of TCM has become another new focus in the research of TCM. New methods and new thoughts such as integrated pharmacokinetics, pharmacokinetics marker,indicated pharmacokinetcs and chromatopharmacokinetics are brought up on the basis of classic research methods, such as blood concentration method,pharmacological method and PK/PD model method. In this paper, we reviewed and commented the progress about the pharmacokinetics study of TCM.