Synthesis of an AIE-active fluorogen and its application in cell imaging |
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| Authors: | Yong Yu YuNing Hong Chao Feng JianZhao Liu Jacky Wing Yip Lam Mahtab Faisal Ka Ming Ng Kathy Qian Luo Ben Zhong Tang |
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| Affiliation: | (1) Department of Chemistry, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay, Hong Kong, China;(2) Department of Chemical and Biomolecular Engineering, HKUST, Clear Water Bay, Kowloon, Hong Kong, China;(3) Bioengineering Graduate Program, HKUST, Clear Water Bay, Kowloon, Hong Kong, China;(4) Institute of Biological and Medical Macromolecules, Zhejiang University, Hangzhou, 310027, China |
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| Abstract: | A fluorogen named 1-decyl-1-methyl-2,5-bis{4-(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as
supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed
highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no
toxicity to the living cells. The fluorogen is thus a promising candidate material for cell imaging as a sensitive, selective
and cytocompatible biosensor.
Supported by the Research Grants Council of Hong Kong (Grant Nos. 603008, 601608 and 602707), the National Natural Science
Foundation of China (Grant No. 20634020) and the CAO GuangBiao Foundation of Zhejiang University. |
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| Keywords: | aggregation-induced emission biosensor cell imaging |
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