少动鞘氨醇单胞菌临床易感因素分析及药物治疗策略

目的:了解医院少动鞘氨醇单胞菌易感因素及耐药特点。方法:回顾性分析7例病原学检查提示少动鞘氨醇单胞菌患者的基础疾病、标本来源、抗菌药物用药史和药物敏感性试验。结果:少动鞘氨醇单胞菌对碳青霉烯类及复方新诺明的敏感性较好，对氨基糖苷类及氟喹诺酮类有一定敏感性，对氨曲南和三代头孢敏感性差。结论:少动鞘氨醇单胞菌宿主易感因素除了以往报道的免疫缺陷、肺部感染、广谱抗生素用药史，还可能存在低蛋白血症及乙型病毒性肝炎病史等因素。治疗用药应避免选择氨曲南及三代头孢。

Sphingomonas paucimobilis analysis of clinical susceptibility factors and drug treatment strategy

AIM: To investigate the susceptibility factors and drug resistance of Sphingomonas paucimobilis in hospital. METHODS: A retrospective analysis of 7 etiology examinations revealed underlying disease, specimen source, antibiotic history, and drug susceptibility testing in patients with Sphingomonas sphaeroides.RESULTS:Sphingomonas sphaeroides had better sensitivity to carbapenems and compound neostigmine, certain sensitivity to aminoglycosides and fluoroquinolones, and poor sensitivity to aztreonam and third generation cephalospores.CONCLUSION: In addition to the previously reported immunodeficiency, pulmonary infection, and broad-spectrum antibiotic history, the predisposing factors of Sphingomonas sphingia may also have factors such as hypoproteinemia and history of hepatitis B virus. Therapeutic medication should avoid the choice of aztreonam and third-generation cephalosporins.