唾液血液尿酸比与糖尿病周围神经病变的相关性

目的探讨2型糖尿病(T2DM)中伴有糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)患者血液尿酸(blood uric acid,BUA)和唾液尿酸(salivary uric acid,SUA)的动态变化,并分析SUA/BUA与DPN的相关性及其预测价值。方法选取2021年1月至2022年12月在我院内分泌科确诊的164例T2DM患者的临床资料,根据临床症状及肌电图等辅助检查结果将所有患者分为DPN组(n=103)和单纯T2DM组(n=61)。检测并比较两组一般资料、SUA以及SUA/BUA情况;多因素Logistic回归分析DPN的相关影响因素;利用受试者工作特征(receiver operator characteristic curve,ROC)曲线评估相关影响因素的预测价值。结果Logistic回归分析结果表明,糖化血红蛋白(glycosylated hemoglobin,HbA 1c)、SUA、SUA/BUA为DPN发生的危险因素。ROC曲线分析表明:HbA 1c的AUC为0.637,敏感度为50.8%,特异度为78.6%,最佳切点值为8.15。SUA的AUC为0.698,敏感度为52.4%,特异度为83.6%,最佳切点值为388.43。BUA的AUC为0.762,敏感度为86.4%,特异度为73.8%,最佳切点值为1.01。结论SUA/BUA与DPN发病密切相关,对诊断DPN有一定预测价值。

Correlation between ratio of salivary uric acid to blood uric acid and diabetic peripheral neuropathy

Objective To explore the dynamic change of blood uric acid (BUA) and salivary uric acid (SUA) in type 2 diabetes mellitus (T2DM) patients with diabetic peripheral neuropathy (DPN), and to study the correlation between ratio of SUA to BUA (SUA/BUA) and DPN, and its predictive value. Methods The clinic data of 164 T2DM patients in the Department of Endocrinology of our hospital from January 2021 to December 2022 was analyzed, and the patients were assigned to the DPN group (n=103) and the simple T2DM group (n=61) based on the clinical symptoms and electromyography results. The general data, SUA and SUA/BUA were compared. The DPN-related factors and their predictive value were respectively assessed by the multiple Logistic regression and receiver operator characteristic (ROC) curve. Results Logistic regression analysis showed that the risk factors of DPN were glycosylated hemoglobin (HbA₁c), SUA, and SUA/BUA. ROC curve analysis showed that areas under curve (AUC), sensitivity, specificity, and optimal cut-off point of HbA₁c were 0.637, 50.8%, 78.6%, and 8.15, respectively, those of SUA were 0.698, 52.4%, 83.6%, 388.43, respectively, and those of BUA were 0.762, 86.4%, 73.8%, 1.01, respectively. Conclusion SUA/BUA is closely associated with DPN, and with a certain predictive value in diagnosis of DPN.