2-丙烯酰胺基-2-甲基丙磺酸合成工艺的新进展

2-丙烯酰胺基-2-甲基丙磺酸（AMPS）的合成方法主要有异丁烯法、异丁醇法、羟基磺酸法、异丁烯磺酸法等，对比反应条件，气相异丁烯法是最温和的，适宜工业化生产。目前异丁烯法已成为主流。为提高产品质量，应从反应下手，改进AMPS的生产工艺。主要改进方法有：合成重结晶一步法、添加试剂法、连续法等。合成重结晶一步法将缩短生产周期，提高生产效率；添加试剂将改善反应性能，提高反应质量；连续法生产AMPS投资少，产品稳定，将成为合成AMPS的趋势。

The Progress in the Synthesis Technique of 2-Acrylamido-2-methylpropanesulfonic Acid

The synthesis method of 2-acrylamido-2-methylpropanesulfonic acid (AMPS) includes isobutylene method,isobutanol method, hydroxysulfonic acid method,methylallylsulfonic acid method,etc.Based on reaction conditions,vapor-isobutylene method is mild among the methods mentioned above,and it is suitable for industrial manufacture.The isobutylene method is becoming popular.In order to enhance the product quality,im- proving the manufacture process of AMPS from the reaction is necessary.The main improving method includes manufacture-recrystallization one step method,adding reagents method,and continuous method,etc.The manufacture-recrystallization one step method will shorten production cycles,and improve production efficiency;adding reagents method will enhance reaction capability;continuous method will cut down investment cost,make the prod- uct stable,and it will become the trend of manufacturing AMPS.