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Benzoic acid, a stimulant of odorant receptors of Bombyx mori, is rapidly metabolized to N-benzoylserine on the antennae |
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| Authors: | Corina Oldenburg Sudha Kanaujia Dieter Spiteller Neil J. Oldham Wilhelm Boland Karl-Ernst Kaissling |
| Affiliation: | Max-Planck-Institut für Verhaltensphysiologie, Seewiesen, Postfach 1564, D-82305 Starnberg, Germany, e-mail: kaissling@ss20.mpi-seewiesen.mpg.de, DE Chemistry Department, G. B. Pant University of Agricultural & Technology, Pantnagar Pin 263145, District Nainital U. P. India, IN Max-Planck-Institut für Chemische ?kologie, Carl-Zeiss-Promenade 10, D-07745 Jena, Germany, DE |
| Abstract: | Summary. Benzoic acid is a known stimulant of olfactory receptor cells in trichoid sensilla on the antennae of adult females of Bombyx mori. Exposure of freshly excised antennae, from B. mori females and males, to vapours of [14C]-benzoic acid revealed that the adsorbed acid is rapidly metabolized (15% conversion in 10 s), suggesting the presence of a highly active enzymatic system. The major product could be identified as N-benzoylserine by use of [2H5]-benzoic acid, and mass spectrometry linked to a gas chromatograph (GC-MS) or a liquid chromatograph (LC-MS), for analysis of the metabolites. The conjugation of benzoic acid with an amino acid apparently represents a novel mode for the rapid deactivation of odorant molecules. Received 26 March 2001. |
| Keywords: | .Bombyx mori— antennae — odorant deactivation — N-benzoylserine — benzoic acid — metabolism |
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