可溶性肿瘤坏死因子受体I在头颈肿瘤患者中的表达及意义

目的研究可溶性肿瘤坏死因子受体I(soluble tumor necrosis factor receptor,sTNFR-I)在头颈部肿瘤患者中的表达及临床意义.方法采用酶联免疫吸附法(enzyme linked immuno sorbent assay,ELISA),检测南京医科大学第一附属医院1997年2月～2000年4月160例头颈部恶性肿瘤患者(其中恶性淋巴瘤12例,鼻咽癌62例,喉癌56例,下咽癌22例,上颌窦癌3例,甲状腺瘤癌5例)血清sTNFR-I的水平(IU/ml,

Expression and significance of serum soluble tumor necrosis factor receptor-I in patients with head and neck neoplasm

Objective To investigate the expression and significance of serum soluble tumor necrosis factor receptor I (sTNFR I) in patients with head and neck neoplasms Method The study was undertaken to detect serum sTNFR I levels in 160 head neck cancer patients (including 12 cases of malignant lymphoma, 62 nasopharyngeal cancer, 56 laryngeal cancer, 22 hypopharyngeal cancer, 3 maxillary cancer and 5 thyrophyma), using Sandwich enzyme linked immuno sorbent assay Results The sTNFR I levels were significantly higher in patients with carcinoma than those of healthy controls ( P <0 01) The sTNFR I levels of malignant lymphoma and nasopharyngeal carcinoma were the highest among patients with head and neck neoplasm The correlations between the serum sTNFR I levels and the stages of head and neck neoplasms and other laboratory parameters were also analyzed and discussed Conclusion The serum sTNFR I levels may reflect the human immunity function, therefore it can be used as a helpful indicator to evaluate the therapeutic effect and monitor the relapses and metastasis of cancer