| 盐酸伐昔洛韦栓的制备及质量控制 |
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| 引用本文： | 孟宪丽,李金伟,杜习智,何西奎. 盐酸伐昔洛韦栓的制备及质量控制[J]. 中国药房, 2007, 18(7): 533-535 |
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| 作者姓名： | 孟宪丽 李金伟 杜习智 何西奎 |
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| 作者单位： | 河南省人民医院药剂科,郑州市,450003 |
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| 摘 要： | 目的:制备盐酸伐昔洛韦栓并建立其质量控制方法。方法:以明胶等为基质制备栓剂;采用高效液相色谱法测定盐酸伐昔洛韦的含量,并考察其稳定性。结果:所制栓剂软硬度合适;盐酸伐昔洛韦检测浓度线性范围为10.1～50.5μg·mL-1(r=0.9998),平均回收率为98.73%(RSD=0.76%,n=3)。结论:该处方制备工艺简单,制剂质量稳定、可控。
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| 关 键 词： | 盐酸伐昔洛韦栓 制备 质量控制 |
| 文章编号： | 1001-0408(2007)07-0533-03 |
| 修稿时间： | 2006-06-08 |
Preparation and Quality Control of Valaciclovir Hydrochloride Suppository |
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| MENG Xianli,LI Jinwei,DU Xizhi,HE Xikui. Preparation and Quality Control of Valaciclovir Hydrochloride Suppository[J]. China Pharmacy, 2007, 18(7): 533-535 |
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| Authors: | MENG Xianli LI Jinwei DU Xizhi HE Xikui |
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| Abstract: | OBJECTIVE: To prepare the valaciclovir hydrochloride suppository and to establish a quality control method. METHODS: The proper base material was gelatin. The valaciclovir hydrochloride was determined by HPLC and the stability test was performed. RESULTS: The prepared suppository had a proper hardness. There was a good linearity of calibration curve of valaciclovir hydrochloride in rang of 10.1～50.5μg·mL-1(r=0.999 8). The average recovery was 98.73%(RSD=0.76%,n=3).The suppository was stable. CONCLUSION: This method was simple, and the formulation thus prepared was stable and controllable in quality. |
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| Keywords: | Valaciclovir hydrochloride suppository Preparation Quality control |
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