| 促甲状腺素释放激素对荷瘤鼠NK和IL－2活性的影响 |
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| 引用本文： | 曲卫敏,陈京,吴敏毓.促甲状腺素释放激素对荷瘤鼠NK和IL－2活性的影响[J].现代免疫学,1996(3). |
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| 作者姓名： | 曲卫敏 陈京 吴敏毓 |
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| 作者单位： | 皖南医学院 |
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| 摘 要： | 本文采用中性红和噻唑蓝比色法，观察了促甲状腺素释放激素（ＴＲＨ）对荷瘤小鼠脾细胞ＮＫ活性和ＩＬ－２产生能力的影响，并研究其抑瘤效应及机理。结果表明：ＴＲＨ能够明显抑制小鼠Ｓ１８０腹水瘤移植物的生长，抑瘤率为５４．６％；并能明显提高荷瘤鼠ＮＫ活性和ＩＬ－２产生能力。这一结果提示ＴＲＨ是一种重要的抗肿瘤免疫调节因子。
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| 关 键 词： | TRH，NK，IL－2，抑瘤作用 |
Effect of Thyrotropin Releasing Hormone on NK and IL-2 Activities in Mice |
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| Qu Weimin, Chen Jing, Wu Minyue.Effect of Thyrotropin Releasing Hormone on NK and IL-2 Activities in Mice[J].Current Immunology,1996(3). |
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| Authors: | Qu Weimin Chen Jing Wu Minyue |
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| Abstract: | The influence of TRH on NK and IL-2 activities in mice was studied. Experimental results showed that TRH giving intraperitoneally to the tumor transplanted mice could reduce the weight of transplanted tumor with a tumor inhibition rate of 54.6%. In addition, it would also improve the NK cell activities and the production of IL-2 in the tumor-bearing mice. It was suggested that TRH was an important antitumor immunoregulator. |
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| Keywords: | TRH NK IL-2 antitumor effect |
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