格瓦斯对大鼠肠道微生物代谢功能的影响

为探究格瓦斯对大鼠肠道轴向微生物代谢功能的影响，通过给大鼠灌胃青霉素钠建立肠道微生物失调大鼠模型，探讨格瓦斯饮料对大鼠体质量变化、排便时间、8 h内排便量、胃动素（MTL）、环磷酸鸟苷（cGMP）和肠道微生物相关指标的影响。结果表明，与模型组比较，格瓦斯给药组大鼠体质量有显著性差异（P＜0.05），格瓦斯高剂量组大鼠的排便量与排便时间有显著性差异（P＜0.05），且显著增加大鼠血清中MTL的含量（P＜0.05），显著降低cGMP水平（P＜0.05），格瓦斯可以显著增加双歧杆菌、乳杆菌数（P＜0.05），显著降低肠杆菌、肠球菌、产气荚膜梭菌、拟杆菌数（P＜0.05）。格瓦斯对于肠道菌群失调导致的微生物代谢功能损伤有一定的拮抗作用，调节肠道微生态。

Effect of kvass on metabolism function of intestinal microbe in rats

In order to investigate the effect of kvass on the metabolic function of axial microorganisms in rat intestine, a rat model of intestinal microbial dysregulation was established by intragastric administration of penicillin sodium, and the effects of kvass on the changes of body mass, defecation time, stool quantity within 8 h, motilin (MTL), cyclic guanosine monophosphate (cGMP) and intestinal microbial related indexes were investigated. The results showed that compared with the model group, there were significant differences in body mass of the kvass-administered group rats (P＜0.05), and there were significant differences in stool quantity and defecation time of the kvass high-dose group rats (P＜0.05), as well as MTL contents in the serum of rats was significantly increased (P＜0.05) and the cGMP level was significantly decreased (P＜0.05). Kvass could significantly increase the number of Bifidobacterium and Lactobacillus (P＜0.05) and significantly decreased the number of Enterobacter, Enterococcus, Clostridium perfringens and Bacteroides (P＜0.05). Kvass had an antagonistic effect on the microbial metabolic function impairment caused by intestinal dysbacteriosis and regulated the intestinal microecology.