Natural okra-based hydrogel for chronic diabetic wound healing |
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| Affiliation: | 1. School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China;2. Center for Nanomedicine and Department of Anesthesiology, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA 02115, United States;3. Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou 510316, China;4. Guizhou University of Chinese Traditional Medicine, Guiyang 550025, China;5. School of Life Science, Jilin University, Changchun 130012, China;6. Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China;7. Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China;1. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;2. State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China;1. Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;2. Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;3. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Hepato-Pancreato-Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China;1. Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry; Key Lab. of Biomass Energy and Material, Jiangsu Province; National Engineering Lab for Biomass Chemical Utilization, Nanjing 210042, China;2. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources; International Innovation Center for Forest Chemicals and Materials College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China;3. Institute of Nanochemistry and Nanobiology School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China;1. College of Pharmaceutical Sciences, Key Laboratory of Public Health Safety of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China;2. College of Basic Medical Science, Key Laboratory for Proteomics of Liaoning Province, Dalian Medical University, Dalian 116044, China;1. Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China;2. School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518057, China;3. Department of Urology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China;1. Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510220, China;2. School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China;3. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China;4. Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China;5. Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China;6. Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People''s Hospital, Qingyuan 511518, China |
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| Abstract: | As a representative of chronic wounds, the long-term high levels of oxidative stress and blood sugar in chronic diabetic wounds lead to serious complications, making them the biggest challenge in the research on wound healing. Many edible natural biomaterials rich in terpenes, phenols, and flavonoids can act as efficient antioxidants. In this study, okra extract was selected as the main component of a wound dressing. The okra extracts obtained via different methods comprehensively maintained the bioactivity of multiple molecules. The robust antioxidant properties of okra significantly reduced intracellular reactive oxygen species production, thereby accelerating the wound healing process. The results showed that okra extracts and their hydrogel dressings increased cell migration, angiogenesis, and re-epithelization of the chronic wound area, considerably promoting wound remodeling in diabetic rats. Therefore, okra-based hydrogels are promising candidates for skin regeneration and wider tissue engineering applications. |
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