| 结合生物信息学的中药组分结构研究思路 |
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| 引用本文： | 王程成,封亮,刘丹,崔莉,谭晓斌,贾晓斌. 结合生物信息学的中药组分结构研究思路[J]. 中国中药杂志, 2015, 40(22): 4514-4519 |
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| 作者姓名： | 王程成 封亮 刘丹 崔莉 谭晓斌 贾晓斌 |
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| 作者单位： | 南京中医药大学, 江苏南京 210046;江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏南京 210028,江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏南京 210028,江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏南京 210028,江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏南京 210028,南京中医药大学第三临床医学院, 江苏南京 210028;江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏南京 210028,南京中医药大学第三临床医学院, 江苏南京 210028;江苏省中医药研究院国家中医药管理局中药释药系统重点研究室, 江苏南京 210028 |
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| 基金项目： | 国家自然科学基金项目(81573620);江苏省333人才项目(BRA2015457);2014年江苏政府留学奖学金项目 |
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| 摘 要： | 中医药属于复杂体系,具有整体性、系统性的特点,组分结构中药是在继承中医药特点的基础上,体现中药多组分整合作用特点的一个有序整体,是中药物质基础的新见解。目前,传统的研究方法不足以解决中医药物质基础与药效关系,多成分、多靶点、多环节作用机制等方面问题。生物信息学诞生于后基因组时代,涉及了系统生物学,不同层面的组学以及相应的数学、计算机科学,越来越成为人们对复杂体系,生命规律本质认识的强大工具。生物信息学的研究思路、技术方法和丰富的数据挖掘知识结合组分结构中药理论,为发展创新组分结构中药,系统解析中医药本质,推动中医药现代化带来新契机。
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| 关 键 词： | 组分结构中药 生物信息学 复杂体系 |
| 收稿时间： | 2015-06-18 |
Research thoughts on structural components of Chinese medicine combined with bioinformatics |
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| WANG Cheng-cheng,FENG Liang,LIU Dan,CUI Li,TAN Xiao-bin and JIA Xiao-bin. Research thoughts on structural components of Chinese medicine combined with bioinformatics[J]. China Journal of Chinese Materia Medica, 2015, 40(22): 4514-4519 |
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| Authors: | WANG Cheng-cheng FENG Liang LIU Dan CUI Li TAN Xiao-bin JIA Xiao-bin |
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| Affiliation: | Nanjing University of Chinese Medicine, Nanjing 210046, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China,Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China,Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China,Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China,The third clinical school of medicine of Nanjing University of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China and The third clinical school of medicine of Nanjing University of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China |
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| Abstract: | Traditional Chinese medicine(TCM) is a complex system, featured with integrity and characteristics. Structural component TCM is a well-organized integrity of traditional Chinese medicine, reflecting multi-component integration effect of TCM. It gives us a new view on the material basis of TCM. Currently, conventional researching strategies are not enough to deal with the relationship between material basis and efficacy, multi-composition, multi-targets, and multi-section mechanism. Post-genome area gives a birth to bioinformatics, which involves systematic biology, different levels of omics, corresponding mathematics and computer techniques. It increasingly becomes a powerful tool to understand complicated system and life essential laws. Research ideas, methods and knowledge of data mining technology of bioinformatics combined with the theory of structural components of Chinese medicine bring a new opportunity for developing structural components of Chinese medicine, systematically exploring the essence of TCM and promoting the modernization of TCM. |
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| Keywords: | structural component Chinese medicine bioinformatics complex system |
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