| 硒多糖对镉中毒大鼠肾保护作用的研究 |
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| 引用本文： | 聂木海,张全新,柳洋,梁晓芸,周颖. 硒多糖对镉中毒大鼠肾保护作用的研究[J]. 实用预防医学, 2005, 12(6): 1311-1312 |
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| 作者姓名： | 聂木海 张全新 柳洋 梁晓芸 周颖 |
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| 作者单位： | 广州市疾病预防控制中心,广东,广州,510080 |
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| 摘 要： | 目的 探讨硒多糖对镉中毒大鼠肾的保护作用。方法 经腹腔注射2．5mg／kg．d氯化镉，连续3d，诱发大鼠肾中毒，同时给大鼠饮用不同剂量的硒多糖水溶液30d，分别测定肾组织匀浆的SOD、GSH-Px的活性，MDA含量，并同时观察大鼠肾组织的形态。结果 硒多糖能明显提升SOD、GSH-Px的括性，显著降低MDA含量，使大鼠肾脏维持正常的生理功能及组织结构。结论 硒多糖对镉中毒大鼠肾损伤有一定的保护作用。
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| 关 键 词： | 硒多糖 镉中毒 肾 保护作用 |
| 文章编号： | 1006-3110（2005）06-1311-02 |
| 收稿时间： | 2005-06-24 |
| 修稿时间： | 2005-06-24 |
Study on Protective Effects of Selenium Polysaccharides on Cadmium Induced Renal Damage of Rat |
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| NIE Mu-hai,ZHANG Quan-xin, LIU Yan,et al.. Study on Protective Effects of Selenium Polysaccharides on Cadmium Induced Renal Damage of Rat[J]. Practical Preventive Medicine, 2005, 12(6): 1311-1312 |
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| Authors: | NIE Mu-hai ZHANG Quan-xin LIU Yan et al. |
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| Affiliation: | Center for Disease Control and Prevention of Guangzhon, Guangzhou 510080, Guangdong , China |
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| Abstract: | Objective Study on the protective effects of selenium polysaccharides on cadmium induced renal damage of rat models. Methods The renal damage of rats were induced by intraperitoneal injection(i.p.) with CdSO_4 2.5 mg/kg,once per day for three days.The experimental groups were fed with selenium polysaccharides solution of different dose for 30 days.Renal tissue morphology and SOD,GSH-Px,MDA activities were examined thereafter. Results Selenium polysaccharides treatment resulted in obvious enhanced activities of SOD and GSH-Px and lowered MDA content,and made the rats' kidney maintained the normal function and tissue morphology. Conclusion Selenium polysaccharides has protective effects on cadmium induced renal damage of rat. |
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| Keywords: | Selenium polysaccharides Cadmium damage Renal Protective effects |
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