阿托伐他汀治疗颈动脉粥样硬化斑块的临床疗效

目的观察阿托伐他汀治疗颈动脉粥样硬化斑块的疗效。方法将66例不同程度颈动脉粥样硬化斑块形成的患者随机分为治疗组和对照组，治疗组服用阿托伐他汀20mg，1d1次，每晚睡前服。对照组服用非诺贝特胶囊0．1g，每日3次。为期6个月，观察治疗前后血脂、颈动脉内膜一中层厚度（IMT）、斑块面积变化。结果治疗组治疗后血清总胆固醇（TC）、血清三酰甘油（TG）、血清低密度脂蛋白（LDL）水平显著下降，血清高密度脂蛋白（HDL）水平显著升高（P〈0．01），IMT、斑块面积减小，与治疗前比较，差异有统计学意义（P〈0．05）。结论阿托伐他汀是治疗颈动脉粥样硬化斑块较好的药物，不但可以降低血脂水平，还能降低斑块面积，值得推广使用。

Clinical efficacy of atorvastatin in treatment of carotid atheroscelerosis

Objective To observe the effects of atorvastatin on treating carotid artery arteriosclerosis plaque. Methods Sixty-six patients With artery arteriosclerosis plaque were randomly divided into the treatment group and the control group, the treatment group took atorvastation 20 mg, once a day, the control group took fenofibrate caps 0.1 g, three times daily. A period of six months. The change of intima-media thickness （IMT） of carotid artery, the area of carotid atherosderotic platue, the change in blood lipids were observed before and after treatment between the two groups. Results After treatment, the serum total cholesterol （TC）, serum triglycericle （TG）, serum low-clemsity lipoprotein （LDL）, levels significantly decreased, serum high-clemsity lipoprotein （HDL） levels were significantly increased （P 〈 0.01）, IMT, plaque area decreased, compared with before treatment, there was significant difference （P 〈 0.05）. Conclusion Atorvastatin can releive atherosclerotic obviously, reduce plaque area, regulate blood lipid, it should be introduced.