| 雷公藤内酯醇对人Th17细胞分化的调节作用 |
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| 引用本文： | 陈鹏远,韩睿,周强,程浩,朱可建. 雷公藤内酯醇对人Th17细胞分化的调节作用[J]. 中国中药杂志, 2011, 36(11): 1499-1502 |
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| 作者姓名： | 陈鹏远 韩睿 周强 程浩 朱可建 |
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| 作者单位： | 浙江大学医学院附属邵逸夫医院皮肤科,浙江杭州,310016 |
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| 摘 要： | 目的:研究雷公藤内酯醇对体外培养的人Th17细胞分化的调节作用.方法:在体外将不同浓度雷公藤内酯醇作用于人外周血单一核细胞、纯化的CD4+T细胞和CD4+CD45RA-记忆性T细胞,采用MTT法检测淋巴细胞增殖,流式细胞术分析单个细胞内表达IL-17和IFN-γ的频数,ELISA法测定细胞分泌IL-17和IFN-γ的水平.结果:雷公藤内酯醇以剂量依赖的方式抑制淋巴细胞增殖、细胞内IL-17的表达频数和细胞产生IL-17的水平.此外,雷公藤内酯醇对细胞内IFN-γ的表达和产生也有抑制作用.结论:雷公藤内酯醇可抑制人TH17细胞的分化,这可能是雷公藤内酯醇免疫抑制和抗炎作用的机制之一.
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| 关 键 词： | 雷公藤内酯醇 Th17细胞 IFN-γ |
| 收稿时间： | 2010-06-23 |
Modulatory effect of triptolide on differentiation of human Th17 cells |
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| CHEN Pengyuan,HAN Rui,ZHOU Qiang,CHENG Hao and ZHU Kejian. Modulatory effect of triptolide on differentiation of human Th17 cells[J]. China Journal of Chinese Materia Medica, 2011, 36(11): 1499-1502 |
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| Authors: | CHEN Pengyuan HAN Rui ZHOU Qiang CHENG Hao ZHU Kejian |
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| Affiliation: | Department of Dermatology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University, Hangzhou 310016, China;Department of Dermatology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University, Hangzhou 310016, China;Department of Dermatology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University, Hangzhou 310016, China;Department of Dermatology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University, Hangzhou 310016, China;Department of Dermatology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University, Hangzhou 310016, China |
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