黄体酮联合盐酸利托君治疗先兆早产效果观察

目的探究黄体酮联合盐酸利托君治疗先兆早产的临床疗效。方法择取2017年6月—2018年12月期间本院收治的60例先兆早产患者为研究对象,根据患者入院时间先后顺序为依据分组,包括对照组与观察组,每组30例。对照组患者行盐酸利托君治疗,观察组患者在盐酸利托君基础上给药黄体酮,比较两组患者保胎成功率、不良反应发生率、药物显效时间、妊娠延长时间、治疗前后血清人绒毛膜促性腺激素(hCG)以及新生儿情况。结果观察组患者保胎成功率96.67%高于对照组73.33%,不良反应发生率10.00%低于对照组33.33%,差异有统计学意义(P<0.05);治疗前组间hCG水平差异无统计学意义(P>0.05),治疗后观察组患者hCG水平显著高于对照组,药物显效时间少于对照组,妊娠延长时间长于对照组,差异有统计学意义(P<0.05);观察组新生儿体质量及Apgar评分高于对照组,宫内窘迫、巨大儿发生率低于对照组,差异有统计学意义(P<0.05)。结论针对先兆早产患者开展黄体酮联合盐酸利托君治疗效果确切,可提升保胎成功率,延长患者妊娠时间,保证新生儿安全性。

Effect of Progesterone Combined With Ritodrine Hydrochloride in the Treatment of Threatened Preterm Labor

Objective To explore the clinical efficacy of progesterone combined with ritodrine hydrochloride in the treatment of threatened preterm labor.Methods 60 cases of patients with preterm labor admitted to our hospital from June 2017 to December 2018 were selected as the study objects.According to the time sequence of admission,the patients were divided into groups,including the control group and the observation group,with 30 cases in each group.Patients in the control group were treated with ritodrine hydrochloride,and patients in the observation group were given progesterone on the basis of ritodrine hydrochloride.The success rate of pregnancy preservation,incidence of adverse reactions,time of drug effect,pregnancy extension,serum human chorionic gonadotropin(hCG)before and after treatment and neonatal condition were compared between the two groups.Results The success rate of foetus preservation in the observation group was 96.67% higher than that in the control group(73.33%),and the incidence of adverse reactions was 10.00% lower than that in the control group(33.33%),the difference was statistically significant(P<0.05).There was no significant difference in hCG level between the two groups before treatment(P>0.05),while the hCG level in the observation group after treatment was significantly higher than that in the control group,the duration of drug effect was shorter than that in the control group,and the pregnancy duration was longer than that in the control group,the difference was statistically significant(P<0.05).The neonatal weight and Apgar score in the observation group were higher than those in the control group,and the incidence of intrauterine distress and macrosomia was lower than that in the control group,with statistically significant differences(P<0.05).Conclusion Progesterone combined with ritodrine hydrochloride is effective in the treatment of threatened preterm labor,which can improve the success rate of pregnancy preservation,prolong the duration of pregnancy and ensure the safety of newborns.