超声造影评价兔肝VX2肿瘤射频消融疗效的研究

目的与组织病理对照，探讨超声造影（contrast enhanced uhrasonography，CEUS）在肝肿瘤射频消融治疗（radiofrequency ablation，RFA）疗效判断中的可靠性。 方法建立8只兔肝VX3肿瘤模型，并进行RFA，有选择地控制消融范围，确保有存活肿瘤组织。在ERFA后4d，CEUS和组织病理检查，比较CEUS获得的消融灶最大径与病理标本的最大径，CEUS切面与病理切片层面基本一致的情况下，分析CEUS与组织病理的相关性。 结果CEUS发现7个消融灶内有残存肿瘤组织，4个消融灶周边出现明显的良性增强带，与组织病理检查对应一致。CEUS获得的消融灶最大径与病理标本的最大径无统计学差异，CEUS和组织病理获得的肝肿瘤坏死成分占病灶总面积的百分比具有良好的相关性（r=0．986）。 结论CEUS在RFA后早期能较准确地鉴别RFA引起的凝固样坏死与残存的肿瘤组织，辨别消融灶周边的良性增强，是评价RFA疗效的有效方法，具有较高的临床应用价值。

Contrast-enhanced Ultrasonographic Assessment on Radiofrequency Ablation in Rabbit Hepatic VX2 Tumors

Objective To explore the reliability of contrast enhanced ultrasonography(CEUS) in assessing the response of heptic tumors after radiofrequency ablation(RFA) compared with histopathology.Methods RFA was applied to 8 rabbit hepatic VX2 tumors to ensure incomplete tumor ablation.CEUS was performed 4 days after RFA and followed with histopathologic examination.The largest diameters of all leasions after RFA on CEUS were compared with that of fresh specimens.CEUS-histopathologic correlation was analyzed to be consistant in CEUS imaging and pathologic specimens.Results Residual tumors were found in 7 of 8 rabbits,and benign periablational enhancement in 4 of 8 lesions(the same as histologic analysis).The difference between the largest diameters after RFA in CEUS and that of fresh specimens was without statistical significance.CEUS correlated well with histopathology in the percentage areas of the necrosis(r=0.986).Conclusions CEUS can accurately discriminate the coagulation necrosis from residual tumors after RFA in a few days,and detect benign periablational enhancement.It is an effective method to adequately assess the suitable treatment of a given tumor.It may play an important role in clinical.