Three new and bioactive icosanoids from the temperate red marine algaFarlowia mollis |
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Authors: | Michele L. Solem Zhi D. Jiang William H. Gerwick |
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Affiliation: | (1) College of Pharmacy, Oregon State University, 97331 Corvallis, OR |
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Abstract: | Three new dihydroxyicosanoids, 12(R),13(R)-dihydroxyicosa-5(Z), 8(Z),10(E),14(Z)-tetraenoic acid, 12(R),13(R)-dihydroxyicosa-5(Z), 8(Z),10(E),10(Z),17(Z)-pentaenoic acid and 10(R*),11(R*)-dihydroxyoctadeca-6(Z),8(E),12(Z)-trienoic acid, have been isolated from a previously unstudied temperate red marine alga,Farlowia mollis (Cryptonemiales, Rhodophyta). The structures of these new metabolites have been deduced from detailed nuclear magnetic resonance and mass spectrometry analyses on stabilized diacetate-methyl esters and stereochemistry deduced by1H NMR couplings and CD analysis of a dibenzoate derivative. Collectively, these new natural products modulate fMLP-induced superoxide anion generation in human neutrophils, inhibit the conversion of arachidonic acid to lipoxygenase products by human neutrophils, and inhibit the functioning of the dog kidney Na+/K+ ATPase. |
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