| 菲牛蛭素体内外抗凝实验研究 |
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| 引用本文： | 黄爱民,黎肇炎,廖共山,黄红坤,班建东,林发全.菲牛蛭素体内外抗凝实验研究[J].广西医科大学学报,2006,23(1):30-32. |
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| 作者姓名： | 黄爱民 黎肇炎 廖共山 黄红坤 班建东 林发全 |
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| 作者单位： | 1. 广西医科大学蛇毒研究所,南宁,530021
2. 广西医科大学第一附属医院实验中心 |
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| 基金项目： | 广西科学研究与技术开发计划项目 |
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| 摘 要： | 目的:研究广西菲牛蛭中提取的两种菲牛蛭素--菲牛蛭素A(Bufrudin A,BA)和菲牛蛭素B(Bufrudin B,BB)在人体外及动物体内的抗凝作用.方法:观察菲牛蛭素在人体外及动物体内对部分活化凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)的影响.结果:在体内外实验中,BA、BB均能明显延长活化部分APTT、PT及TT,但两者的三个指标有明显差异性,其中BA对TT的作用最显著,BB则对PT的作用更强.结论:广西菲牛蛭中的抗凝物质BA、BB在体内外均有较强的抗凝活性.
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| 关 键 词： | 广西菲牛蛭 菲牛蛭素 抗凝作用 |
| 收稿时间： | 2005-04-18 |
| 修稿时间： | 2005年4月18日 |
THE ANTICOAGULANT EFFECT OF BUFRUDIN ON HUMAN PLASMA IN VITRO AND RABBIT PLASMA IN VIVO |
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| Huang Aimin, Li Zhaoyan,Liao Gongsan,et al..THE ANTICOAGULANT EFFECT OF BUFRUDIN ON HUMAN PLASMA IN VITRO AND RABBIT PLASMA IN VIVO[J].Journal of Guangxi Medical University,2006,23(1):30-32. |
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| Authors: | Huang Aimin Li Zhaoyan Liao Gongsan |
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| Affiliation: | Snake Venom Research Institute of Guangxi Medical University, Nanning 530021 China |
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| Abstract: | Objective:To study the anticoagulating effect of Bufrudin purified from Guangxi hirudinaria manillensis on human and rabbit plasma coagulations.Methods:To assay anticoagulating activities of BA and BB by activated partial thromboplastin time(APTT), prothrombin time(PT),thrombin time (TT) on human and rabbit plasma coagulations in vitro and in vivo. Result:Both proteins, BA and BB, could prolong the activated partial thromboplsatin time(APTT), thrombin time (TT) and prothrombin time(PT), with obvious difference. BA affected strongly during thrombin time (TT), but BB affected more during prothrombin time(PT). Conclusion:Both anticoagulantion proteins, BA and BB, have strong anticoagulantion activity in vivo or invitro. |
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| Keywords: | Guangxi hirudinaria manillensis Bufrudin anticoagulating effect |
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