肝血窦在内毒素致肝损伤中的作用 |
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引用本文: | 赵利利,袁东亚,孙芳云.肝血窦在内毒素致肝损伤中的作用[J].临床肝胆病杂志,2016(1):182-184. |
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作者姓名: | 赵利利 袁东亚 孙芳云 |
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作者单位: | 西藏民族大学医学院 生命科学基础研究实验室,陕西 咸阳,712082 |
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基金项目: | 2014年西藏自治区科技厅自然科学基金 |
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摘 要: | 内毒素是革兰阴性菌细胞壁中的特有成分,又称脂多糖(LPS)。肝脏既是清除细菌和内毒素的场所,又是最易受损的器官。肝损伤最初发生在肝血窦。主要介绍了LPS对Kupffer细胞、肝窦内皮细胞、肝血窦中氧化/抗氧化平衡及肝脏血流的影响。认为肝血窦在LPS所造成的肝损伤中的作用不容忽视,研究其对防治LPS致肝损伤有重要意义。
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关 键 词: | 肝疾病 脂多糖类 枯否细胞 综述 |
Role of hepatic sinusoids in lipopolysaccharide-induced liver injury |
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Abstract: | Endotoxin,which is also called lipopolysaccharide (LPS),is a unique element of Gram-negative bacteria.Liver is the main site for removing bacteria and endotoxin.Meanwhile,it is also the most vulnerable organ.Liver injury initially occurs in the hepatic sinu-soids.This article mainly introduces the impact of LPS on Kupffer cells,hepatic sinusoidal endothelial cells,oxidant/antioxidant balance in the hepatic sinusoids,and liver blood flow.It is believed that the function of hepatic sinusoids in LPS-induced liver injury should not be ig-nored,and the hepatic sinusoids would play an important role in the prevention and treatment of LPS-induced liver injury. |
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Keywords: | liver diseases lipopolysaccharides kupffer cells review |
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