Center for Integrated Protein Science Munich (CiPSM), Department of Chemistry and Biochemistry, Ludwig‐Maximilians‐Universit?t München, Butenandtstrasse 5‐13, 81377 Munich (Germany), Fax: (+49)?89‐2180‐77656
Abstract:
Disarmed forces : Inhibition of the central virulence regulator ClpP by structurally refined β‐lactones resulted in dramatically reduced production of devastating virulence factors, including pyrogenic toxin superantigens derived from pathogenic multiresistant Staphylococcus aureus strains. Targeting of this virulence regulator could present an attractive strategy for neutralizing the harmful effects of bacterial pathogens, and help the host immune response to eliminate the disarmed bacteria.
