[M(CO)2(NO)], a new core in bioorganometallic chemistry: model complexes of [Re(CO)2(NO)] and [Tc(CO)2(NO)] |
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| Authors: | D Rattat A Verbruggen H Berke |
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| Affiliation: | a Laboratory of Radiopharmaceutical Chemistry, University of Leuven, B-3000 Leuven, Belgium
b Institute of Inorganic Chemistry, University of Zurich, CH-8057 Zurich, Switzerland |
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| Abstract: | In this study selected bidentate (L2) and tridentate (L3) ligands were coordinated to the Re(I) or Tc(I) core M(CO)2(NO)]2+ resulting in complexes of the general formula fac-MX(L2)(CO)2(NO)] and fac-M(L3)(CO)2(NO)] (M = Re or Tc; X = Br or Cl). The complexes were obtained directly from the reaction of M(CO)2(NO)]2+ with the ligand or indirectly by first reacting the ligand with M(CO)3]+ and subsequent nitrosylation with NO]BF4] or NO]HSO4]. Most of the reactions were performed with cold rhenium on a macroscopic level before the conditions were adapted to the n.c.a. level with technetium (99mTc). Chloride, bromide and nitrate were used as monodentate ligands, picolinic acid (PIC) as a bidentate ligand and histidine (HIS), iminodiacetic acid (IDA) and nitrilotriacetic acid (NTA) as tridentate ligands. We synthesised and describe the dinuclear complex ReCl(μ-Cl)(CO)2(NO)]2 and the mononuclear complexes NEt4]ReCl3(CO)2(NO)], NEt4]ReBr3(CO)2(NO)], ReBr(PIC)(CO)2(NO)], NMe4]Re(NO3)3(CO)2(NO)], Re(HIS)(CO)2(NO)]BF4], 99Tc(HIS)(CO)2(NO)]BF4], 99mTc(IDA)(CO)2 (NO)] and 99mTc(NTA)(CO)2(NO)]. The chemical and physical characteristics of the Re and Tc-dicarbonyl-nitrosyl complexes differ significantly from those of the corresponding tricarbonyl compounds. |
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| Keywords: | Nitrosyl Carbonyl Radiopharmaceuticals Organometallic Rhenium Technetium |
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