超声引导下经皮激光消融与射频消融治疗微小肝细胞癌的疗效对比 |
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引用本文: | 陈颖,易照雄,刘正敏,严婷,徐洁. 超声引导下经皮激光消融与射频消融治疗微小肝细胞癌的疗效对比[J]. 国际肿瘤学杂志, 2016, 0(12): 900-903. DOI: 10.3760/cma.j.issn.1673-422X.2016.12.005 |
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作者姓名: | 陈颖 易照雄 刘正敏 严婷 徐洁 |
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作者单位: | 723000,陕西省汉中市三二一医院超声科 |
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摘 要: | 目的:通过与超声引导下经皮射频消融(RFA)比较,观察超声引导下经皮激光消融(LA)治疗微小肝细胞癌(HCC)的临床疗效。方法回顾性分析54例微小 HCC 患者的临床资料,按照治疗方法的不同将其分为 LA 组(n =27)和 RFA 组(n =27)。LA 组患者接受超声引导下 LA 治疗,RFA 组接受超声引导下 RFA 治疗,观察近期疗效及不良反应,随访患者的肿瘤局部控制率和无进展生存期(PFS)。结果LA 组和 RFA 组患者治疗后的总有效率分别为81.48%、77.78%,差异无统计学意义(χ2=0.11,P =0.74);两组患者1年肿瘤局部控制率分别为77.78%、51.85%,差异有统计学意义(χ2=14.74,P =0.00);两组患者中位 PFS 分别为(12.52±6.57)个月和(8.67±5.13)个月,差异有统计学意义(χ2=4.70,P =0.03)。LA 组和 RFA 组治疗后出现的不良反应如穿刺区域疼痛(40.74%∶33.33%;χ2=0.32,P =0.57)、腹腔出血(7.41%∶11.11%;P =0.64)、胆道出血(0∶3.70%;P =0.31)、胆漏(7.41%∶14.81%;P =0.39)、腹腔感染(3.70%∶11.11%;P =0.30)的差异均无统计学意义。结论与 RFA 比较,LA 可提高微小 HCC 患者的肿瘤局部控制率,并延长患者的 PFS,具有一定的临床应用价值和前景。
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关 键 词: | 癌,肝细胞 导管消融术 无进展生存期 |
Effect comparison between ultrasound guided percutaneous laser ablation and radiofrequency ablation for the treatment of small hepatocellular carcinoma |
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Abstract: | Objective To compare the effects between ultrasound guided percutaneous laser ablation (LA)and radiofrequency ablation (RFA)for small hepatocellular carcinoma (HHC).Methods We retro-spectively reviewed the data of 54 patients with small HHC.According to the different methods of treatment,54 patients were divided into LA group (n =27)and RFA group (n =27).Patients in LA group were treated with ultrasound guided percutaneous LA,and patients in RFA group were treated with RFA.The adverse reaction and short-term curative effect were observed.The local tumor control rate and progression-free survival (PFS) of patients were follow-up visited.Results After treatment,the total response rates of patients in LA group and RFA group were 81 .48% and 77.78% respectively,with no significant difference (χ2 =0.1 1 ,P =0.74).The 1 -year local tumor control rates of patients in LA group and RFA group were 77.78% and 51 .85%respectively,with a significant difference (χ2 =1 4.74,P =0.00).The median PFS of patients in LA group and RFA group were (1 2.52 ±6.57)months and (8.67 ±5.1 3)months,with a significant difference (χ2 =4.70,P =0.03).The adverse reactions of patients in LA group and RFA group after treatment were puncture region pain (40.74% vs.33.33%;χ2 =0.32,P =0.57),retroperitoneal hemorrhage (7.41 % vs.1 1 .1 1 %;P =0.64),hemobilia (0 vs.3.70%;P =0.31 ),bile leakage (7.41 % vs.1 4.81 %;P =0.39),and ab-dominal infection (3.70% vs.1 1 .1 1 %;P =0.30),with no significant differences.Conclusion Compared with RFA,LA may improve the local tumor control rate and prolong the PFS of patients with small HHC,which has a certain clinical practice value and prospect. |
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Keywords: | Carcinoma,hepatocellular Catheter ablation Progression-free survival |
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