苯乙酸溶解度测定及提取工艺研究

为了提取6-氨基青霉烷酸(6-APA)、7-ADCA生产过程中产生的副产物苯乙酸,采用物理法测定了苯乙酸在水、水-乙醇、水-丙酮中的溶解度及其在水中的溶解速率,由此确定了水法多次提取的工艺方案。结果表明,在提取温度(60±2)℃,时间10~15 m in,水用量1 500 mL,提取次数3~4次时,苯乙酸收率为90.8%,纯度为99.3%。该法污染少、成本低,所得PAA产品质量好。

Study on the determination of PAA solubility and the extraction technology

In order to extract the by-product phenyl acetic acid from the production process of 6-APA,7-ADCA,the solubility of phenyl acetic acid in water,water-alcohol,water-acetone,and the solution rate in water were determined through the physical method.Accordingly,the technique of multiextraction with water was determined.The experimental result indicated: the yield of phenyl acetic acid was 90.8% and the purity was 99.3%,when the extraction temperature is(60±2) ℃,the time is 10~15 min,the water amount is 1 500 mL,the extraction times is 3~4.The method had such advantages as low pollution,low costs,good quality of PAA product.