PRF促进急性创面愈合的研究进展

伤口愈合很大程度上依赖于机体自身的修复能力，而组织损伤会激活多种细胞分泌生长因子参与炎症反应过程，调节蛋白质和其他细胞成分的合成、分解，从而促进细胞增殖、基质形成、血管再生及肉芽形成，达到创面修复的目的。富血小板纤维蛋白（PRF）是第二代血小板浓缩物，与富血小板血浆（PRP）不同，PRF制备时未加入抗凝剂和其他化学成分，有效避免了过敏反应。PRF富含生长因子，可持续释放生长因子至少1周以上，同时具有良好的立体纤维蛋白空间结构，可为创面提供理想的细胞支架，能有效促使细胞迁移和增殖，从而达到促进创面愈合的作用。本文为探究PRF促进急性创面愈合的研究进展，现就伤口愈合过程、PRF应用于急性伤口愈合时的作用机制作一综述。

Research Progress of PRF in Promoting Acute Wound Healing

Wound healing is largely dependent on the body''s own repair capacity, and tissue damage can activate a variety of cells to secrete growth factors to participate in the inflammatory response process, regulate the synthesis and decomposition of proteins and other cellular components, thereby promoting cell proliferation, matrix formation, angiogenesis and granulation formation, to achieve the purpose of wound repair. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate. Unlike platelet-rich plasma (PRP), PRF is prepared without anticoagulants and other chemical components, which effectively avoids allergic reactions. PRF is rich in growth factors and can continuously release growth factors for at least 1 week. At the same time, it has a good three-dimensional fibrin space structure, which can provide an ideal cell scaffold for the wound, effectively promote cell migration and proliferation, and thus promote wound healing. In order to explore the research progress of PRF in promoting acute wound healing, this paper reviews the wound healing process and the mechanism of PRF in acute wound healing.