魔芋葡甘聚糖/聚乙烯醇纳米纤维膜及其释药行为研究

为了研制药物缓释效果优良的薄膜材料,利用静电纺丝设备研制不同比重的魔芋葡甘露聚糖/聚乙烯醇纳米纤维膜,并通过扫描电镜、傅里叶变换红外光谱和示差扫描量热法表征纳米纤维膜的结构和性能,结合体外实验和数学模型研究其缓释行为.结果显示当魔芋葡甘露聚糖含量占纳米纤维膜总质量约76%时,纳米纤维膜中微纤丝粗细最均匀且结点较少,纳米纤维膜中魔芋葡甘聚糖和聚乙烯醇之间存在明显的相互作用,含有5-氨基水杨酸的纳米纤维膜在pH=7.4 PBS磷酸盐缓冲液中25 h的累积释放量大约为45%,显示出良好的药物缓释效果,其缓释行为与Higuchi模型具有较高的拟合度.研究表明利用静电纺丝设备研制的魔芋葡甘聚糖/聚乙烯醇纳米纤维膜可以为药物缓释载体的开发提供理论依据.

Konjac Glucomannan/Poly(vinyl alcohol) Nanofiber Film and Its Drug Release Behavior

Nanofiber films froms different proportion of konjac glucomannan (KGM)/poly(vinyl alcohol) (PVA) have been synthesized using electrospinning and used for sustained drug release.KGM was crosslinked with PVA to form a composite liquid,which was used as spinning solution to prepare KGM-PVA film by electrospinning.The drug release behavior of KGM-PVA nanofiber membrane was studied using 5-ASA as model drug.The microstructure of the composite nanofiber films was characterized by scanning electron microscope (SEM) and Fourier transform infrared spectrometer (FTIR),while the thermal properties were analyzed by differential scanning calorimeter (DSC).The sustained-release of the model drug from the nanofiber films was studied in vitro and with a mathematical model of drug release.It was observed that a uniform nanofiber with no node was synthesized when about 76％ of KGM in the nanofibers film was used.Under this condition,thermal stability was enhanced as well.The structure characterization illustrated that the nanofiber membrane of the composite KGM-PVA was formed by stacking of the numerous nanofibers.Intermolecular reaction between KGM and PVA led to an enormous change in the structure and the function of the composite films in comparison with other KGM derived films.A relatively large specific surface area was formed during the formation of the network structure in the nanofiber film,which favored drug adsorption.The in vitro experiment results revealed that nanofiber film containing 5-aminosalicylic acid in PBS buffer of pH =7.4,performed well sustained-release and the cumulative release rate was about 45％ after 25 h.The results also showed sustained-release from the nanofiber films was better fitted with Higuchi model.This study indicated that KGM/PVA nanofiber film developed by electro spinning provided a theoretical base for the development of the carrier for sustainable drug-release.