| 3-甲基-5-吡唑酮的合成研究 |
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| 引用本文： | 刘福胜,于世涛,周昕,葛晓萍. 3-甲基-5-吡唑酮的合成研究[J]. 化学世界, 2003, 44(8): 426-427,421 |
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| 作者姓名： | 刘福胜 于世涛 周昕 葛晓萍 |
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| 作者单位： | 青岛科技大学化工与制药工程学院,山东,青岛,266042 |
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| 摘 要： | 采用乙酰乙酸乙酯和水合肼为原料 ,无水乙醇为溶剂 ,对 3-甲基 - 5 -吡唑酮的合成反应进行了研究 ,在反应温度为 80°C,乙酰乙酸乙酯与水合肼摩尔比为 1∶ 1 .2 ,反应时间 3h的较佳工艺条件下 ,产物收率大于 85 % ,产物纯度大于 99.5 %。用 IR光谱对产物结构进行了确认
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| 关 键 词： | 3-甲基-5-吡唑酮 乙酰乙酸乙酯 水合肼 合成 |
| 文章编号： | 0367-6358(2003)08-0426-03 |
Study on Synthesis of 3-Methyl-5-pyrazolone |
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| LIU Fu sheng,YU Shi tao,ZHOU Xin,GE Xiao ping. Study on Synthesis of 3-Methyl-5-pyrazolone[J]. Chemical World, 2003, 44(8): 426-427,421 |
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| Authors: | LIU Fu sheng YU Shi tao ZHOU Xin GE Xiao ping |
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| Abstract: | The synthesis of 3 methyl 5 pyrazolone from ethyl acetoacetate and hydrazine hydrate using ethanol as solvent was studied. The optimum reaction conditions were: reaction temperature, 80°C; n (3 methyl 5 pyrazolone)∶ n (hydrazine hydrate)=1∶1.2; reaction time, 3 h. The yield of the product was ≥85% and the purity was ≥99.5%. |
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| Keywords: | methyl 5 pyrazolone ethyl acetoacetate hydrazine hydrate synthesis |
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